Novel Oxycellulose/Gelatin Nanofibers for Medical Applications

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00086963" target="_blank" >RIV/00216224:14310/15:00086963 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216305:26310/15:PU116720

Výsledek na webu

<a href="http://www.fch.vutbr.cz/media/sok/sbornik_prispevku_2015.pdf" target="_blank" >http://www.fch.vutbr.cz/media/sok/sbornik_prispevku_2015.pdf</a>

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Novel Oxycellulose/Gelatin Nanofibers for Medical Applications

Popis výsledku v původním jazyce

Novel hydrolytically stable gelatin nanofibers were modified with sodium or calcium salts of oxidized cellulose (oxycellulose) to enhance nanofibers? stability and bactericidal efficiency. The unique inhibitory effect of the electrospun gelatin/ oxycellulose nanofibers against pathogenic bacteria was examined by luminometric method using modified bioluminescence of E. coli strain. Non-woven nanofiber fabric has been tested for its biocompatibility using human lung adenocarcinoma cells line NCI-H441. Cells cultured on nanofibrous materials firmly adhered to their surface without the changing in shape, as determined by scanning electron microscopy, and did not show any signs of dying as revealed by live/death staining via fluorescence microscope. This newly developed nanofibrous material seeded with NCI-H441 cell line could be therefore used as a platform for lung disease modeling and anti-cancer drug testing.

Název v anglickém jazyce

Novel Oxycellulose/Gelatin Nanofibers for Medical Applications

Popis výsledku anglicky

Novel hydrolytically stable gelatin nanofibers were modified with sodium or calcium salts of oxidized cellulose (oxycellulose) to enhance nanofibers? stability and bactericidal efficiency. The unique inhibitory effect of the electrospun gelatin/ oxycellulose nanofibers against pathogenic bacteria was examined by luminometric method using modified bioluminescence of E. coli strain. Non-woven nanofiber fabric has been tested for its biocompatibility using human lung adenocarcinoma cells line NCI-H441. Cells cultured on nanofibrous materials firmly adhered to their surface without the changing in shape, as determined by scanning electron microscopy, and did not show any signs of dying as revealed by live/death staining via fluorescence microscope. This newly developed nanofibrous material seeded with NCI-H441 cell line could be therefore used as a platform for lung disease modeling and anti-cancer drug testing.

Druh

O - Ostatní výsledky

CEP obor

BL - Fyzika plasmatu a výboje v plynech

OECD FORD obor

—

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů