Stable Gelatin Nanofibers Modified with Oxidized Cellulose for Soft Tissue Engineering
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F15%3A00086961" target="_blank" >RIV/00216224:14310/15:00086961 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00216305:26310/15:PU115578
Výsledek na webu
<a href="http://www.fch.vutbr.cz/media/chl_2015/images/BoA_CHL2015.pdf" target="_blank" >http://www.fch.vutbr.cz/media/chl_2015/images/BoA_CHL2015.pdf</a>
DOI - Digital Object Identifier
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Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Stable Gelatin Nanofibers Modified with Oxidized Cellulose for Soft Tissue Engineering
Popis výsledku v původním jazyce
The present work deals with the preparation of (bio) polymer nanofibers by Nanospider technology. The obtained nanofibers are biocompatible, bioadhesive, porous and mimic the structure of the extracellular matrix forming the structure of tissues. Gelatinnanofibers modified by addition of sodium or calcium salt of oxidized cellulose were successfully prepared. Gelatin is a biocompatible and biodegradable polymer. Oxidized cellulose and its salts are biocompatible, biodegradable and they also exhibit hemostatic and bactericidal efficiency. Crosslinking process was an another important step to improve hydrolytic stability and mechanical properties of nanofibers. H441 cell lines (human papillary adenocarcinoma cells) were seeded on prepared electrospun nanofibers. The viability of H441 cell lines on nanofibers was evaluated. Newly prepared material may have a potential application in surgery and regenerative medicine of soft tissues (e. g. decubitus and burns).
Název v anglickém jazyce
Stable Gelatin Nanofibers Modified with Oxidized Cellulose for Soft Tissue Engineering
Popis výsledku anglicky
The present work deals with the preparation of (bio) polymer nanofibers by Nanospider technology. The obtained nanofibers are biocompatible, bioadhesive, porous and mimic the structure of the extracellular matrix forming the structure of tissues. Gelatinnanofibers modified by addition of sodium or calcium salt of oxidized cellulose were successfully prepared. Gelatin is a biocompatible and biodegradable polymer. Oxidized cellulose and its salts are biocompatible, biodegradable and they also exhibit hemostatic and bactericidal efficiency. Crosslinking process was an another important step to improve hydrolytic stability and mechanical properties of nanofibers. H441 cell lines (human papillary adenocarcinoma cells) were seeded on prepared electrospun nanofibers. The viability of H441 cell lines on nanofibers was evaluated. Newly prepared material may have a potential application in surgery and regenerative medicine of soft tissues (e. g. decubitus and burns).
Klasifikace
Druh
O - Ostatní výsledky
CEP obor
BL - Fyzika plasmatu a výboje v plynech
OECD FORD obor
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Návaznosti výsledku
Projekt
Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů