Infulence of glucose 3-O-methylation on binding properties towards PLL2 lectin

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F19%3A00107347" target="_blank" >RIV/00216224:14310/19:00107347 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Infulence of glucose 3-O-methylation on binding properties towards PLL2 lectin

Popis výsledku v původním jazyce

In protein-sugar interaction, the sugar OH groups are generally considered as the main interacting groups participating in ligand binding via hydrogen bonds. However, recent findings demonstrate the importance of non-polar interactions, such as CH-PI interactions between aromatic amino acids and apolar part of carbohydrate molecules. One of the modifications which increase the hydrophobicity of the molecule is O-methylation. O-methylation of sugars is an uncommon modification with not fully understood function. Recently, it was described as a pathogen-associated molecular pattern (PAMP) recognized during innate immune response. In order to assess the role of O-methyl groups on sugar recognition, we determined a structure of bacterial lectin PLL2 in complex with d-glucose (d-Glc) or 3-O-methyl-d-glucose (3OMG), respectively .

Název v anglickém jazyce

Infulence of glucose 3-O-methylation on binding properties towards PLL2 lectin

Popis výsledku anglicky

In protein-sugar interaction, the sugar OH groups are generally considered as the main interacting groups participating in ligand binding via hydrogen bonds. However, recent findings demonstrate the importance of non-polar interactions, such as CH-PI interactions between aromatic amino acids and apolar part of carbohydrate molecules. One of the modifications which increase the hydrophobicity of the molecule is O-methylation. O-methylation of sugars is an uncommon modification with not fully understood function. Recently, it was described as a pathogen-associated molecular pattern (PAMP) recognized during innate immune response. In order to assess the role of O-methyl groups on sugar recognition, we determined a structure of bacterial lectin PLL2 in complex with d-glucose (d-Glc) or 3-O-methyl-d-glucose (3OMG), respectively .

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

10600 - Biological sciences

Projekt

<a href="/cs/project/GA18-18964S" target="_blank" >GA18-18964S: Lektiny a jejich úloha v interakci patogen/hostitel a buněčném rozpoznávání</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů