Can We Pharmacologically Target Dishevelled: The Key Signal Transducer in the Wnt Pathways?
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F21%3A00123816" target="_blank" >RIV/00216224:14310/21:00123816 - isvavai.cz</a>
Výsledek na webu
<a href="https://link.springer.com/chapter/10.1007/164_2021_527" target="_blank" >https://link.springer.com/chapter/10.1007/164_2021_527</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1007/164_2021_527" target="_blank" >10.1007/164_2021_527</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Can We Pharmacologically Target Dishevelled: The Key Signal Transducer in the Wnt Pathways?
Popis výsledku v původním jazyce
Dishevelled (DVL) is the central signal transducer in both Wnt/β-catenin-dependent and independent signalling pathways. DVL is required to connect receptor complexes and downstream effectors. Since proximal Wnt pathway components and DVL itself are upregulated in many types of cancer, DVL represents an attractive therapeutic target in the Wnt-addicted cancers and other disorders caused by aberrant Wnt signalling. Here, we discuss progress in several approaches for the modulation of DVL function and hence inhibition of the Wnt signalling. Namely, we sum up the potential of modulation of enzymes that control post-translational modification of DVL - such as inhibition of DVL kinases or promotion of DVL ubiquitination and degradation. In addition, we discuss research directions that can take advantage of direct interaction with the protein domains essential for DVL function: the inhibition of DIX- and DEP-domain mediated polymerization and interaction of DVL PDZ domain with its ligands.
Název v anglickém jazyce
Can We Pharmacologically Target Dishevelled: The Key Signal Transducer in the Wnt Pathways?
Popis výsledku anglicky
Dishevelled (DVL) is the central signal transducer in both Wnt/β-catenin-dependent and independent signalling pathways. DVL is required to connect receptor complexes and downstream effectors. Since proximal Wnt pathway components and DVL itself are upregulated in many types of cancer, DVL represents an attractive therapeutic target in the Wnt-addicted cancers and other disorders caused by aberrant Wnt signalling. Here, we discuss progress in several approaches for the modulation of DVL function and hence inhibition of the Wnt signalling. Namely, we sum up the potential of modulation of enzymes that control post-translational modification of DVL - such as inhibition of DVL kinases or promotion of DVL ubiquitination and degradation. In addition, we discuss research directions that can take advantage of direct interaction with the protein domains essential for DVL function: the inhibition of DIX- and DEP-domain mediated polymerization and interaction of DVL PDZ domain with its ligands.
Klasifikace
Druh
C - Kapitola v odborné knize
CEP obor
—
OECD FORD obor
30104 - Pharmacology and pharmacy
Návaznosti výsledku
Projekt
<a href="/cs/project/EF16_025%2F0007381" target="_blank" >EF16_025/0007381: Preklinická progrese nových organických sloučenin s cílenou biologickou aktivitou</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2021
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název knihy nebo sborníku
Pharmacology of the WNT Signaling System
ISBN
9783030854980
Počet stran výsledku
19
Strana od-do
117-135
Počet stran knihy
422
Název nakladatele
Springer
Místo vydání
Cham (Švýcarsko)
Kód UT WoS kapitoly
—