Can We Pharmacologically Target Dishevelled: The Key Signal Transducer in the Wnt Pathways?

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68081707%3A_____%2F21%3A00604836" target="_blank" >RIV/68081707:_____/21:00604836 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216224:14310/21:00123816

Výsledek na webu

<a href="https://link.springer.com/chapter/10.1007/164_2021_527" target="_blank" >https://link.springer.com/chapter/10.1007/164_2021_527</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/164_2021_527" target="_blank" >10.1007/164_2021_527</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Can We Pharmacologically Target Dishevelled: The Key Signal Transducer in the Wnt Pathways?

Popis výsledku v původním jazyce

Dishevelled (DVL) is the central signal transducer in both Wnt/beta-catenin-dependent and independent signalling pathways. DVL is required to connect receptor complexes and downstream effectors. Since proximal Wnt pathway components and DVL itself are upregulated in many types of cancer, DVL represents an attractive therapeutic target in the Wnt-addicted cancers and other disorders caused by aberrant Wnt signalling. Here, we discuss progress in several approaches for the modulation of DVL function and hence inhibition of the Wnt signalling. Namely, we sum up the potential of modulation of enzymes that control post-translational modification of DVL such as inhibition of DVL kinases or promotion of DVL ubiquitination and degradation. In addition, we discuss research directions that can take advantage of direct interaction with the protein domains essential for DVL function: the inhibition of DIX- and DEP-domain mediated polymerization and interaction of DVL PDZ domain with its ligands.

Název v anglickém jazyce

Can We Pharmacologically Target Dishevelled: The Key Signal Transducer in the Wnt Pathways?

Popis výsledku anglicky

Dishevelled (DVL) is the central signal transducer in both Wnt/beta-catenin-dependent and independent signalling pathways. DVL is required to connect receptor complexes and downstream effectors. Since proximal Wnt pathway components and DVL itself are upregulated in many types of cancer, DVL represents an attractive therapeutic target in the Wnt-addicted cancers and other disorders caused by aberrant Wnt signalling. Here, we discuss progress in several approaches for the modulation of DVL function and hence inhibition of the Wnt signalling. Namely, we sum up the potential of modulation of enzymes that control post-translational modification of DVL such as inhibition of DVL kinases or promotion of DVL ubiquitination and degradation. In addition, we discuss research directions that can take advantage of direct interaction with the protein domains essential for DVL function: the inhibition of DIX- and DEP-domain mediated polymerization and interaction of DVL PDZ domain with its ligands.

Druh

C - Kapitola v odborné knize

CEP obor

—

OECD FORD obor

10608 - Biochemistry and molecular biology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

PHARMACOLOGY OF THE WNT SIGNALING SYSTEM

ISBN

978-3-030-85498-0

Počet stran výsledku

19

Strana od-do

"Roč. 269"

Počet stran knihy

422

Název nakladatele

Springer Nature Link

Místo vydání

Heidelberg

Kód UT WoS kapitoly

001286792100007