What Orangutans Can Teach Us: Plants Used for Self-medication as a Potential Source of Bioactive Substances with Antiparasitic Effects

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F23%3A00139717" target="_blank" >RIV/00216224:14310/23:00139717 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

What Orangutans Can Teach Us: Plants Used for Self-medication as a Potential Source of Bioactive Substances with Antiparasitic Effects

Popis výsledku v původním jazyce

The main aim of this work is the isolation, identification and examination of bioactive plant fractions with potential antiparasitic activity. These extracts are obtained from plants that are routinely eaten by orangutans. Our previous research suggests that the purpose of this consumption is self-medication. The main criteria for the plant selection are the behavioral data of the orangutans and the parasite infections thereof. The effect of these extracts on the progression of significant waterborne protozoal diseases (WBD), namely amoebiasis and giardiasis, is tested using both in vitro and in vivo methods. Moreover, the anthelmintic properties of the selected extract are investigated in vivo in a model nematode, Caenorhabditis elegans. Subsequently, activityguided fractionation is performed and active substances from these extracts are isolated and their chemical structure and biological activities are characterized.

Název v anglickém jazyce

What Orangutans Can Teach Us: Plants Used for Self-medication as a Potential Source of Bioactive Substances with Antiparasitic Effects

Popis výsledku anglicky

The main aim of this work is the isolation, identification and examination of bioactive plant fractions with potential antiparasitic activity. These extracts are obtained from plants that are routinely eaten by orangutans. Our previous research suggests that the purpose of this consumption is self-medication. The main criteria for the plant selection are the behavioral data of the orangutans and the parasite infections thereof. The effect of these extracts on the progression of significant waterborne protozoal diseases (WBD), namely amoebiasis and giardiasis, is tested using both in vitro and in vivo methods. Moreover, the anthelmintic properties of the selected extract are investigated in vivo in a model nematode, Caenorhabditis elegans. Subsequently, activityguided fractionation is performed and active substances from these extracts are isolated and their chemical structure and biological activities are characterized.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30310 - Parasitology

Projekt

<a href="/cs/project/GA23-06571S" target="_blank" >GA23-06571S: Co nás mohou naučit orangutani: protiamébová a protigiardiová aktivita rostlin používaných orangutany k možné sebemedikaci</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů