Apoptotic DNA fragmentation in tissues of pigs with cardiopulmonary bypass (CPB)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14310%2F98%3A00004075" target="_blank" >RIV/00216224:14310/98:00004075 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Apoptotic DNA fragmentation in tissues of pigs with cardiopulmonary bypass (CPB)

Popis výsledku v původním jazyce

The goal of this work was to show whether apoptosis would be activated in pigs in the course of cardiopulmonary bypass (CPB), and whether the results obtained on a pig exemplar could be used for the investigation of protection of human myocardium. CPB was carried out by usual procedure on 10 minipigs. Apoptotic cells with extensive DNA fragmentation were found in the bone marrow after chest opening before CPB. This could reflect the reaction of bone marrow to the preoperative stress. After the operationa decrease in the number of nuclei with extensive DNA fragmentation was observed in the tested animals. On the other hand a marked prevalence of bone marrow cells with nuclei with extensive apoptotic fragmentation was found in the dead animals. It was shown that apoptotic DNA fragmentation of myocardial tissue was chiefly all peoved at the end of the operation. However, it was not detected in pulmonary tissues.

Název v anglickém jazyce

Apoptotic DNA fragmentation in tissues of pigs with cardiopulmonary bypass (CPB)

Popis výsledku anglicky

The goal of this work was to show whether apoptosis would be activated in pigs in the course of cardiopulmonary bypass (CPB), and whether the results obtained on a pig exemplar could be used for the investigation of protection of human myocardium. CPB was carried out by usual procedure on 10 minipigs. Apoptotic cells with extensive DNA fragmentation were found in the bone marrow after chest opening before CPB. This could reflect the reaction of bone marrow to the preoperative stress. After the operationa decrease in the number of nuclei with extensive DNA fragmentation was observed in the tested animals. On the other hand a marked prevalence of bone marrow cells with nuclei with extensive apoptotic fragmentation was found in the dead animals. It was shown that apoptotic DNA fragmentation of myocardial tissue was chiefly all peoved at the end of the operation. However, it was not detected in pulmonary tissues.

Druh

B - Odborná kniha

CEP obor

EB - Genetika a molekulární biologie

OECD FORD obor

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Projekt

<a href="/cs/project/IZ1924" target="_blank" >IZ1924: Postperfuzní syndrom II.</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

1998

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

ISBN

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Počet stran knihy

1

Název nakladatele

European Hematology Assotiation - ECDO

Místo vydání

Švédsko

Kód UT WoS knihy

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