IGH Rearrangement Evolution in Adult <i>KMT2A</i>-rearranged B-cell Precursor ALL: Implications for Cell-of-origin and MRD Monitoring

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F23%3A00133316" target="_blank" >RIV/00216224:14740/23:00133316 - isvavai.cz</a>

Výsledek na webu

<a href="https://journals.lww.com/hemasphere/fulltext/2023/01000/igh_rearrangement_evolution_in_adult.6.aspx" target="_blank" >https://journals.lww.com/hemasphere/fulltext/2023/01000/igh_rearrangement_evolution_in_adult.6.aspx</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1097/HS9.0000000000000820" target="_blank" >10.1097/HS9.0000000000000820</a>

Jazyk výsledku

angličtina

Název v původním jazyce

IGH Rearrangement Evolution in Adult <i>KMT2A</i>-rearranged B-cell Precursor ALL: Implications for Cell-of-origin and MRD Monitoring

Popis výsledku v původním jazyce

B lymphoid neoplasms originate from a single malignantly transformed immune cell, whose immunoglobulin heavy chain (IGH) rearrangement profile is carried by the entire expanded malignant population and mirrors its differentiation status. However, in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) and depending on the developmental stage of malignant transformation, multiple new but related IGH rearrangements may result from RAG-mediated recombination that may still be active in the malignant clone. Moreover, such phenomena complicate the identification of molecular minimal residual disease (MRD) markers and have implications for MRD monitoring. Therefore, deep analysis of IGH gene rearrangement patterns and clonal evolution mechanisms may allow new insights into the stage of B-cell differentiation arrest of the leukemia-driving subpopulation that ultimately determines the outcome, and provide more accurate MRD results.

Název v anglickém jazyce

IGH Rearrangement Evolution in Adult <i>KMT2A</i>-rearranged B-cell Precursor ALL: Implications for Cell-of-origin and MRD Monitoring

Popis výsledku anglicky

B lymphoid neoplasms originate from a single malignantly transformed immune cell, whose immunoglobulin heavy chain (IGH) rearrangement profile is carried by the entire expanded malignant population and mirrors its differentiation status. However, in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) and depending on the developmental stage of malignant transformation, multiple new but related IGH rearrangements may result from RAG-mediated recombination that may still be active in the malignant clone. Moreover, such phenomena complicate the identification of molecular minimal residual disease (MRD) markers and have implications for MRD monitoring. Therefore, deep analysis of IGH gene rearrangement patterns and clonal evolution mechanisms may allow new insights into the stage of B-cell differentiation arrest of the leukemia-driving subpopulation that ultimately determines the outcome, and provide more accurate MRD results.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30205 - Hematology

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

HemaSphere

ISSN

2572-9241

e-ISSN

2572-9241

Svazek periodika

7

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

1-4

Kód UT WoS článku

000901500500004

EID výsledku v databázi Scopus

2-s2.0-85144941419