Chromatin Complexity in Cancer: Unraveling the Impact of Complex Structural Variations in Chronic Lymphocytic Leukemia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216224%3A14740%2F24%3A00138141" target="_blank" >RIV/00216224:14740/24:00138141 - isvavai.cz</a>

Výsledek na webu

<a href="https://meetings.embo.org/event/24-chromatin-bio" target="_blank" >https://meetings.embo.org/event/24-chromatin-bio</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Chromatin Complexity in Cancer: Unraveling the Impact of Complex Structural Variations in Chronic Lymphocytic Leukemia

Popis výsledku v původním jazyce

Chromatin in interphase nuclei has a hierarchical 3D structure consisting of compartments, topologically associated domains (TADs), and loops, all of which are essential for molecular processes. Numerous studies suggest that changes in chromatin organization can lead to cancer transformation. We address this phenomenon in chronic lymphocytic leukemia (CLL), the most common type of leukemia in adults. While some simple structural variations (SVs) are known to cause genetic mutations in CLL driver genes, complex SVs are far from being understood. We aim to investigate the functional consequences of complex SVs in CLL to shed light on the disease's development and progression.

Název v anglickém jazyce

Chromatin Complexity in Cancer: Unraveling the Impact of Complex Structural Variations in Chronic Lymphocytic Leukemia

Popis výsledku anglicky

Chromatin in interphase nuclei has a hierarchical 3D structure consisting of compartments, topologically associated domains (TADs), and loops, all of which are essential for molecular processes. Numerous studies suggest that changes in chromatin organization can lead to cancer transformation. We address this phenomenon in chronic lymphocytic leukemia (CLL), the most common type of leukemia in adults. While some simple structural variations (SVs) are known to cause genetic mutations in CLL driver genes, complex SVs are far from being understood. We aim to investigate the functional consequences of complex SVs in CLL to shed light on the disease's development and progression.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30204 - Oncology

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů