Sensitive voltammetric method for determination of chemotherapeutic drug methotrexate using liquid mercury free silver solid amalgam electrode

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F14%3A39898015" target="_blank" >RIV/00216275:25310/14:39898015 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Sensitive voltammetric method for determination of chemotherapeutic drug methotrexate using liquid mercury free silver solid amalgam electrode

Popis výsledku v původním jazyce

Voltammetric behavior of a wide-spread used chemotherapeutic drug methotrexate (MTX) has been investigated on a polished silver solid amalgam electrode (p-AgSAE) employing various voltammetric methods like cyclic voltammetry, direct current voltammetry and differential pulse voltammetry. It was found that MTX provided two reduction and one oxidation peak in an acidic medium and the positively situated reduction signal (Ep = -340 mV), due its favorable analytical properties, was studied more in detail. 0.05 mol L-1 acetate buffer of pH 5 was selected as an optimal medium for monitoring of the MTX reduction on p-AgSAE. Operating parameters of differential pulse voltammetry were optimized and proposed voltammetric method provided high repeatability (relative standard deviation of 11 repeated measurements at concentration level of methotrexate of 1x10-7 mol L-1 equaled to 1.7%), linear concentration range from 5x10-10 to 3x10-6 mol L-1 and low limit of detection (LD = 1.5x10-10 mol L-1). T

Název v anglickém jazyce

Sensitive voltammetric method for determination of chemotherapeutic drug methotrexate using liquid mercury free silver solid amalgam electrode

Popis výsledku anglicky

Voltammetric behavior of a wide-spread used chemotherapeutic drug methotrexate (MTX) has been investigated on a polished silver solid amalgam electrode (p-AgSAE) employing various voltammetric methods like cyclic voltammetry, direct current voltammetry and differential pulse voltammetry. It was found that MTX provided two reduction and one oxidation peak in an acidic medium and the positively situated reduction signal (Ep = -340 mV), due its favorable analytical properties, was studied more in detail. 0.05 mol L-1 acetate buffer of pH 5 was selected as an optimal medium for monitoring of the MTX reduction on p-AgSAE. Operating parameters of differential pulse voltammetry were optimized and proposed voltammetric method provided high repeatability (relative standard deviation of 11 repeated measurements at concentration level of methotrexate of 1x10-7 mol L-1 equaled to 1.7%), linear concentration range from 5x10-10 to 3x10-6 mol L-1 and low limit of detection (LD = 1.5x10-10 mol L-1). T

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CG - Elektrochemie

OECD FORD obor

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Projekt

<a href="/cs/project/EE2.3.30.0021" target="_blank" >EE2.3.30.0021: Posílení excelentních týmů výzkumu a vývoje na Univerzitě Pardubice</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scientific Papers of the University of Pardubice, Series A, Faculty of Chemical Technology

ISSN

1211-5541

e-ISSN

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Svazek periodika

20

Číslo periodika v rámci svazku

září 2014

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

16

Strana od-do

131-146

Kód UT WoS článku

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EID výsledku v databázi Scopus

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