Synthesis, structural characterization, antimicrobial and antifungal activity of substituted 6-?uorobenzo[d]thiazole amides

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F15%3A39899908" target="_blank" >RIV/00216275:25310/15:39899908 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1007/s00044-015-1410-0" target="_blank" >http://dx.doi.org/10.1007/s00044-015-1410-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00044-015-1410-0" target="_blank" >10.1007/s00044-015-1410-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis, structural characterization, antimicrobial and antifungal activity of substituted 6-?uorobenzo[d]thiazole amides

Popis výsledku v původním jazyce

A series of novel 1-[(1R)-1-(6-?uoro-1,3-benzothiazol-2-yl)ethyl]-3-substituted phenyl amides was synthesized by the condensation reaction of (1R)-1-(6-?uoro-1,3-benzothiazol-2-yl)ethanamine with substituted benzoyl chlorides under mild conditions. Theirstructures were con?rmed by 1H NMR, 13C NMR and 19F NMR spectra, elemental analyses and in three cases also by single-crystal X-ray diffraction techniques. The optical activities were con?rmed by optical rotation measurements. All the synthesized compounds were screened for antibacterial and antifungal activity against a variety of bacterial and fungal strains. Some of the compounds reveal antibacterial and antifungal activity comparable or slightly better to that of chloramphenicol, cefoperazone and amphotericin B used as medicinal standards.

Název v anglickém jazyce

Synthesis, structural characterization, antimicrobial and antifungal activity of substituted 6-?uorobenzo[d]thiazole amides

Popis výsledku anglicky

A series of novel 1-[(1R)-1-(6-?uoro-1,3-benzothiazol-2-yl)ethyl]-3-substituted phenyl amides was synthesized by the condensation reaction of (1R)-1-(6-?uoro-1,3-benzothiazol-2-yl)ethanamine with substituted benzoyl chlorides under mild conditions. Theirstructures were con?rmed by 1H NMR, 13C NMR and 19F NMR spectra, elemental analyses and in three cases also by single-crystal X-ray diffraction techniques. The optical activities were con?rmed by optical rotation measurements. All the synthesized compounds were screened for antibacterial and antifungal activity against a variety of bacterial and fungal strains. Some of the compounds reveal antibacterial and antifungal activity comparable or slightly better to that of chloramphenicol, cefoperazone and amphotericin B used as medicinal standards.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CC - Organická chemie

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Medicinal Chemistry Research

ISSN

1054-2523

e-ISSN

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Svazek periodika

24

Číslo periodika v rámci svazku

2015

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

3660-3670

Kód UT WoS článku

000360508300006

EID výsledku v databázi Scopus

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