Determination of Methotrexate at a Silver Solid Amalgam Electrode by Differential Pulse Voltammetry

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F16%3A39901439" target="_blank" >RIV/00216275:25310/16:39901439 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1080/00032719.2014.996812" target="_blank" >http://dx.doi.org/10.1080/00032719.2014.996812</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/00032719.2014.996812" target="_blank" >10.1080/00032719.2014.996812</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Determination of Methotrexate at a Silver Solid Amalgam Electrode by Differential Pulse Voltammetry

Popis výsledku v původním jazyce

An ultrasensitive voltammetric method is reported for the determination of methotrexate using a polished modified silver solid amalgam electrode. Electrochemical behavior of this compound was examined using cyclic, linear sweep, and differential pulse voltammetry. Methotrexate provided two reduction and one oxidation signal in acidic and neutral media. The first reduction peak (E-p=-350 millivolts vs. Ag|AgCl electrode) and supporting electrolyte of pH 5 was chosen for further experiments. Differential pulse voltammetry parameters were optimized in combination with adsorptive stripping and the applicability of the method was verified. A low limit of detection (1.5x10(-10)moles per liter), good repeatability of determination (relative standard deviation<3.5%, n=5), and good repeatability of measurements (relative standard deviation of 1.7% at 1.0x10(-7)mole per liter methotrexate and n=11) was obtained. The method was employed for the accurate determination of methotrexate in a chemotherapeutic preparation.

Název v anglickém jazyce

Determination of Methotrexate at a Silver Solid Amalgam Electrode by Differential Pulse Voltammetry

Popis výsledku anglicky

An ultrasensitive voltammetric method is reported for the determination of methotrexate using a polished modified silver solid amalgam electrode. Electrochemical behavior of this compound was examined using cyclic, linear sweep, and differential pulse voltammetry. Methotrexate provided two reduction and one oxidation signal in acidic and neutral media. The first reduction peak (E-p=-350 millivolts vs. Ag|AgCl electrode) and supporting electrolyte of pH 5 was chosen for further experiments. Differential pulse voltammetry parameters were optimized in combination with adsorptive stripping and the applicability of the method was verified. A low limit of detection (1.5x10(-10)moles per liter), good repeatability of determination (relative standard deviation<3.5%, n=5), and good repeatability of measurements (relative standard deviation of 1.7% at 1.0x10(-7)mole per liter methotrexate and n=11) was obtained. The method was employed for the accurate determination of methotrexate in a chemotherapeutic preparation.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Analytical Letters

ISSN

0003-2719

e-ISSN

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Svazek periodika

49

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

13

Strana od-do

122-134

Kód UT WoS článku

000363048900011

EID výsledku v databázi Scopus

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