Preparation of hyaluronan nanoparticles using different cross-linking strategies

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216275%3A25310%2F18%3A39913032" target="_blank" >RIV/00216275:25310/18:39913032 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216275:25520/18:39913032

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Preparation of hyaluronan nanoparticles using different cross-linking strategies

Popis výsledku v původním jazyce

Nowadays the use of drug-delivery systems becomes more and more popular. The use of supporting medium for drug substances is used to delay and control the drug release. Biodegradable polymers, such as hyaluronic acid, represent the most natural materials beneficially used for such systems. In this work we focused on the preparation of hyaluronic acid nanoparticles using low-molecular weight HA (LMW-HA; 11 and 30 kDa). This form of HA is used rarely because the size of the obtained particles is usually higher than in case of the high-molecular weight form. Lower size of particles is beneficial for its easier administration, distribution in the body, and the potential for cellular uptake of nanoparticles and its cytotoxicity. To verify the suitability of LMW-HA for the preparation of nano-scale particles, different cross-linking strategies were used. The hydrodynamic diameters of prepared nanoparticles and the structure compactness were then compared.

Název v anglickém jazyce

Preparation of hyaluronan nanoparticles using different cross-linking strategies

Popis výsledku anglicky

Nowadays the use of drug-delivery systems becomes more and more popular. The use of supporting medium for drug substances is used to delay and control the drug release. Biodegradable polymers, such as hyaluronic acid, represent the most natural materials beneficially used for such systems. In this work we focused on the preparation of hyaluronic acid nanoparticles using low-molecular weight HA (LMW-HA; 11 and 30 kDa). This form of HA is used rarely because the size of the obtained particles is usually higher than in case of the high-molecular weight form. Lower size of particles is beneficial for its easier administration, distribution in the body, and the potential for cellular uptake of nanoparticles and its cytotoxicity. To verify the suitability of LMW-HA for the preparation of nano-scale particles, different cross-linking strategies were used. The hydrodynamic diameters of prepared nanoparticles and the structure compactness were then compared.

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

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OECD FORD obor

10404 - Polymer science

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach<br>I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Scientific Papers of the University of Pardubice, Series A, Faculty of Chemical Technology

ISSN

1211-5541

e-ISSN

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Svazek periodika

24

Číslo periodika v rámci svazku

November

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

10

Strana od-do

49-58

Kód UT WoS článku

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EID výsledku v databázi Scopus

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