Nanoparticles formed by self-assembly of negatively charged hyaluronan and cationic surfactant

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F13%3APU107763" target="_blank" >RIV/00216305:26310/13:PU107763 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Nanoparticles formed by self-assembly of negatively charged hyaluronan and cationic surfactant

Popis výsledku v původním jazyce

Physico-chemical interactions in hyaluronan-surfactant system result in nanoparticles formation which can be used in targeted delivery of hydrophobic active substances. The aim of our study was to prepare hyaluronic acid nanoparticles based on electrostatic interactions with oppositely charged molecules. Particles were investigated using dynamic light scattering and Laser Doppler Velocimetry methods. Size distribution and zeta potential measurement were utilized to explore the formation of complex micelles. Particles size distributions depend on type of solvent, molecular weight of hyaluronan and charge ratio of components of the hyaluronan-surfactant system. Aggregates formation is influenced by preparation of the system. Stability of the micellar particles depends on zeta potential value.

Název v anglickém jazyce

Nanoparticles formed by self-assembly of negatively charged hyaluronan and cationic surfactant

Popis výsledku anglicky

Physico-chemical interactions in hyaluronan-surfactant system result in nanoparticles formation which can be used in targeted delivery of hydrophobic active substances. The aim of our study was to prepare hyaluronic acid nanoparticles based on electrostatic interactions with oppositely charged molecules. Particles were investigated using dynamic light scattering and Laser Doppler Velocimetry methods. Size distribution and zeta potential measurement were utilized to explore the formation of complex micelles. Particles size distributions depend on type of solvent, molecular weight of hyaluronan and charge ratio of components of the hyaluronan-surfactant system. Aggregates formation is influenced by preparation of the system. Stability of the micellar particles depends on zeta potential value.

Druh

O - Ostatní výsledky

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/LD12068" target="_blank" >LD12068: Příprava koloidů hyaluronanu s micelárními agregáty pro nanomedicínské aplikace a charakterizace jejich vlastností</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů