Self-Assembly Behavior of Negatively Charged Hyaluronan and Oppositely Charged Surfactants

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F14%3APU110562" target="_blank" >RIV/00216305:26310/14:PU110562 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Self-Assembly Behavior of Negatively Charged Hyaluronan and Oppositely Charged Surfactants

Popis výsledku v původním jazyce

Physico-chemical interactions between negatively charged hyaluronan and positively charged surfactant result in self-assembly nanoparticles formation. The aim of our study was to prepare and study hyaluronic acid nanoparticles based on electrostatic interactions with oppositely charged surfactant molecules. Interactions of hyaluronan and surfactants were investigated using dynamic light scattering and Laser Doppler Velocimetry methods. Titration experiments (size distribution and zeta potential measurement and isoelectric point) were utilized to explore the formation of aggregates. Aggregates formation is influenced by preparation of system. Different particles are formed if hyaluronan is added to surfactant solution or vice versa. Molecular weights ofhyaluronan have inconsiderable effect on interactions of components. If hyaluronan have a role of titrant, final particles are smaller than in the case of surfactant as titrant and can be more suitable for drug delivery applications. Pre

Název v anglickém jazyce

Self-Assembly Behavior of Negatively Charged Hyaluronan and Oppositely Charged Surfactants

Popis výsledku anglicky

Physico-chemical interactions between negatively charged hyaluronan and positively charged surfactant result in self-assembly nanoparticles formation. The aim of our study was to prepare and study hyaluronic acid nanoparticles based on electrostatic interactions with oppositely charged surfactant molecules. Interactions of hyaluronan and surfactants were investigated using dynamic light scattering and Laser Doppler Velocimetry methods. Titration experiments (size distribution and zeta potential measurement and isoelectric point) were utilized to explore the formation of aggregates. Aggregates formation is influenced by preparation of system. Different particles are formed if hyaluronan is added to surfactant solution or vice versa. Molecular weights ofhyaluronan have inconsiderable effect on interactions of components. If hyaluronan have a role of titrant, final particles are smaller than in the case of surfactant as titrant and can be more suitable for drug delivery applications. Pre

Druh

O - Ostatní výsledky

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/LD12068" target="_blank" >LD12068: Příprava koloidů hyaluronanu s micelárními agregáty pro nanomedicínské aplikace a charakterizace jejich vlastností</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů