STUDY OF NANOPARTICLES FORMED BY NEGATIVELY CHARGED HYALURONAN AND CATIONIC SURFACTANTS USING LIGHT SCATTERING TECHNIQUES

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F14%3APU110556" target="_blank" >RIV/00216305:26310/14:PU110556 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

STUDY OF NANOPARTICLES FORMED BY NEGATIVELY CHARGED HYALURONAN AND CATIONIC SURFACTANTS USING LIGHT SCATTERING TECHNIQUES

Popis výsledku v původním jazyce

Negatively charged hyaluronan binds to cationic surfactant via electrostatic interactions which result in self-assembly nanoparticles formation. These particles have a core-shell like structure and can be used in targeted drug delivery of hydrophobic active substances. The aim of our study was to prepare and study these systems using dynamic light scattering methods. Titration experiments (size distribution and zeta potential measurements) were utilized to explore the formation of aggregates. Hyaluronan or surfactant was used as titrant for comparison of two preparation methods of these systems. Effect of molecular weight and concentration of hyaluronan were investigated. Aggregates formation is influenced by preparation of systems. Different types of particles are formed if hyaluronan is added to surfactant solution or vice versa. If hyaluronan have a role of titrant, final particles are smaller than in the case of surfactant as titrant and can be more suitable for drug delivery applications.

Název v anglickém jazyce

STUDY OF NANOPARTICLES FORMED BY NEGATIVELY CHARGED HYALURONAN AND CATIONIC SURFACTANTS USING LIGHT SCATTERING TECHNIQUES

Popis výsledku anglicky

Negatively charged hyaluronan binds to cationic surfactant via electrostatic interactions which result in self-assembly nanoparticles formation. These particles have a core-shell like structure and can be used in targeted drug delivery of hydrophobic active substances. The aim of our study was to prepare and study these systems using dynamic light scattering methods. Titration experiments (size distribution and zeta potential measurements) were utilized to explore the formation of aggregates. Hyaluronan or surfactant was used as titrant for comparison of two preparation methods of these systems. Effect of molecular weight and concentration of hyaluronan were investigated. Aggregates formation is influenced by preparation of systems. Different types of particles are formed if hyaluronan is added to surfactant solution or vice versa. If hyaluronan have a role of titrant, final particles are smaller than in the case of surfactant as titrant and can be more suitable for drug delivery applications.

Druh

O - Ostatní výsledky

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/LD12068" target="_blank" >LD12068: Příprava koloidů hyaluronanu s micelárními agregáty pro nanomedicínské aplikace a charakterizace jejich vlastností</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů