Biomechanical rupture risk assessment of abdominal aortic aneurysms based on a novel probabilistic rupture risk index

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F15%3APU116545" target="_blank" >RIV/00216305:26210/15:PU116545 - isvavai.cz</a>

Výsledek na webu

<a href="http://rsif.royalsocietypublishing.org/content/12/113/20150852" target="_blank" >http://rsif.royalsocietypublishing.org/content/12/113/20150852</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1098/rsif.2015.0852" target="_blank" >10.1098/rsif.2015.0852</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Biomechanical rupture risk assessment of abdominal aortic aneurysms based on a novel probabilistic rupture risk index

Popis výsledku v původním jazyce

Background. A rupture risk assessment is critical to the clinical treatment of Abdominal Aortic Aneurysm (AAA) patients. The biomechanical AAA rupture risk assessment quantitatively integrates many known AAA rupture risk factors but the variability of risk predictions due to model input uncertainties remains a challenging limitation. Methods. The present study derives a Probabilistic Rupture Risk Index (PRRI). Specifically, the uncertainties in AAA wall thickness and wall strength were considered, and wall stress was predicted with a state-of-the-art deterministic biomechanical model. The discriminative power of PRRI was tested in a diameter-matched cohort of ruptured (n=7) and intact (n=7) AAAs and compared to alternative risk assessment methods. Results. Computed PRRI at 1.5 Mean Arterial Pressure was significantly (p=0.041) higher in ruptured AAAs (20.21(SD14.15%) than in intact AAAs (3.71(SD 5.77)%). PRRI showed a high sensitivity and specificity (discriminative power of 0.837) to discriminate between ruptured and intact AAA cases. The underlying statistical representation of stochastic data of wall thickness, wall strength and Peak Wall Stress (PWS) had only negligible effects on PRRI computations. Conclusion. Uncertainties in AAA wall stress predictions, the wide range of reported wall strength and the stochastic nature of failure motivate a probabilistic rupture risk assessment. Advanced AAA biomechanical modeling paired with a probabilistic rupture index definition as known from engineering risk assessment seems to be superior to a purely deterministic approach.

Název v anglickém jazyce

Biomechanical rupture risk assessment of abdominal aortic aneurysms based on a novel probabilistic rupture risk index

Popis výsledku anglicky

Background. A rupture risk assessment is critical to the clinical treatment of Abdominal Aortic Aneurysm (AAA) patients. The biomechanical AAA rupture risk assessment quantitatively integrates many known AAA rupture risk factors but the variability of risk predictions due to model input uncertainties remains a challenging limitation. Methods. The present study derives a Probabilistic Rupture Risk Index (PRRI). Specifically, the uncertainties in AAA wall thickness and wall strength were considered, and wall stress was predicted with a state-of-the-art deterministic biomechanical model. The discriminative power of PRRI was tested in a diameter-matched cohort of ruptured (n=7) and intact (n=7) AAAs and compared to alternative risk assessment methods. Results. Computed PRRI at 1.5 Mean Arterial Pressure was significantly (p=0.041) higher in ruptured AAAs (20.21(SD14.15%) than in intact AAAs (3.71(SD 5.77)%). PRRI showed a high sensitivity and specificity (discriminative power of 0.837) to discriminate between ruptured and intact AAA cases. The underlying statistical representation of stochastic data of wall thickness, wall strength and Peak Wall Stress (PWS) had only negligible effects on PRRI computations. Conclusion. Uncertainties in AAA wall stress predictions, the wide range of reported wall strength and the stochastic nature of failure motivate a probabilistic rupture risk assessment. Advanced AAA biomechanical modeling paired with a probabilistic rupture index definition as known from engineering risk assessment seems to be superior to a purely deterministic approach.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10610 - Biophysics

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of the Royal Society Interface

ISSN

1742-5689

e-ISSN

1742-5662

Svazek periodika

113

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

1-11

Kód UT WoS článku

000367807000016

EID výsledku v databázi Scopus

2-s2.0-84954141217