Finite element simulation of mechanical tests with bendo-tensegrity models of smooth muscle cell.

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F16%3APU121107" target="_blank" >RIV/00216305:26210/16:PU121107 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Finite element simulation of mechanical tests with bendo-tensegrity models of smooth muscle cell.

Popis výsledku v původním jazyce

It is now evident that microtubules do not have compression-only behavior but appear highly curved in living cells under no external load. This indicates that the compressive forces in them are accompanied by significant bending even if loaded solely by the prestrained actin bundles; this is referred to as the “bendo-tensegrity” concept. Implementing this concept, finite element models of smooth muscle cell (SMC) are proposed considering the dominating role of flexion in behavior of microtubules. A Finite element simulation of atomic force microscopy (AFM) experiment with adherent cell model and tensile test with suspended cell model is performed. The numerically predicted force-displacement curves of both simulations are analogous to the non-linear experimental responses obtained with AFM and tensile test for SMC; this validates the proposed bendo-tensegrity cell models. Results show that the actin cortex plays a vital role in maintaining the cell rigidity under local deformation, whereas the microfi

Název v anglickém jazyce

Finite element simulation of mechanical tests with bendo-tensegrity models of smooth muscle cell.

Popis výsledku anglicky

It is now evident that microtubules do not have compression-only behavior but appear highly curved in living cells under no external load. This indicates that the compressive forces in them are accompanied by significant bending even if loaded solely by the prestrained actin bundles; this is referred to as the “bendo-tensegrity” concept. Implementing this concept, finite element models of smooth muscle cell (SMC) are proposed considering the dominating role of flexion in behavior of microtubules. A Finite element simulation of atomic force microscopy (AFM) experiment with adherent cell model and tensile test with suspended cell model is performed. The numerically predicted force-displacement curves of both simulations are analogous to the non-linear experimental responses obtained with AFM and tensile test for SMC; this validates the proposed bendo-tensegrity cell models. Results show that the actin cortex plays a vital role in maintaining the cell rigidity under local deformation, whereas the microfi

Druh

O - Ostatní výsledky

CEP obor

BO - Biofyzika

OECD FORD obor

—

Projekt

<a href="/cs/project/LO1202" target="_blank" >LO1202: NETME CENTRE PLUS</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů