In vitro investigation of inhalation delivery of nebulized liposomes

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F22%3APU146718" target="_blank" >RIV/00216305:26210/22:PU146718 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

In vitro investigation of inhalation delivery of nebulized liposomes

Popis výsledku v původním jazyce

Inhalation therapy is a promising way of drug delivery, but the suitable carrier system plays an important role in its effectiveness. The inhalation administration of two nebulized liposomal systems was investigated in this study. The first system contained dipalmitoylfosfatidylcholine (DPPC), polyethylene glycol (PEG) bonded to dipalmitoylphosphoethanolamine (DPPE), and cholesterol (Chol). The second one consisted of DPPC, phosphatidic acid (PA), and Chol. These systems were nebulized by 2 air-jet nebulizers (AJN): Pari LC Sprint, and Pari LC Sprint Star. The stability during nebulization was assessed for both systems and both nebulizers. Aerodynamic Particle Size Distribution (APSD) of nebulized aerosols was measured. According to the results of the stability and APSD (MMADLC_Sprint_Star 7.39 ± 0.24 µm; MMADLC_Sprint 9.79 ± 0.41 µm), the air-jet nebulizer PARI LC Sprint Star and DPPC-PA-Chol liposomal system were selected as the most promising choice among the tested cases. This combination was used

Název v anglickém jazyce

In vitro investigation of inhalation delivery of nebulized liposomes

Popis výsledku anglicky

Inhalation therapy is a promising way of drug delivery, but the suitable carrier system plays an important role in its effectiveness. The inhalation administration of two nebulized liposomal systems was investigated in this study. The first system contained dipalmitoylfosfatidylcholine (DPPC), polyethylene glycol (PEG) bonded to dipalmitoylphosphoethanolamine (DPPE), and cholesterol (Chol). The second one consisted of DPPC, phosphatidic acid (PA), and Chol. These systems were nebulized by 2 air-jet nebulizers (AJN): Pari LC Sprint, and Pari LC Sprint Star. The stability during nebulization was assessed for both systems and both nebulizers. Aerodynamic Particle Size Distribution (APSD) of nebulized aerosols was measured. According to the results of the stability and APSD (MMADLC_Sprint_Star 7.39 ± 0.24 µm; MMADLC_Sprint 9.79 ± 0.41 µm), the air-jet nebulizer PARI LC Sprint Star and DPPC-PA-Chol liposomal system were selected as the most promising choice among the tested cases. This combination was used

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

20303 - Thermodynamics

Projekt

<a href="/cs/project/GA22-20357S" target="_blank" >GA22-20357S: Měření a počítačová simulace transportu vláknitých aerosolů v proudění s vysokými gradienty rychlosti a interakce vláken se stěnou</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů