Deposition of nebulized liposomal carriers within an upper airways replica

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26210%2F22%3APU147047" target="_blank" >RIV/00216305:26210/22:PU147047 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Deposition of nebulized liposomal carriers within an upper airways replica

Popis výsledku v původním jazyce

Lung cancer is the most deadly cancer disease (18 % of deaths are caused by cancer) (Sung et al., 2021). Cancer treatment is connected with severe side effects due to whole-body exposure to strong cytotoxic anticancer drugs (Zhang et al., 2018). Inhalation treatment could decrease the exposure of the healthy organs and eliminate the side effects. Liposomal carrier systems are a perspective option of inhalation delivery of anticancer drugs, because of their biocompatibility, the longer retention in the lung, or targeted cellular therapy (Young et al., 2015). The liposome from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) stabilized by cholesterol phosphatidic acid (PA) was nebulized by Pari LC Sprint Star nebulizer (Pari GmbH, Germany). MMAD (Mass Median Aerodynamic Diameter) of generated aerosol measured by Aerodynamic Particle Sizer (APS, TSI Inc., Minnesota) was 7.27±0.26 µm and GSD (Geometric Standard Deviation) was 1.54±0.01 µm. The deposition of a nebulized system in a replica of the huma

Název v anglickém jazyce

Deposition of nebulized liposomal carriers within an upper airways replica

Popis výsledku anglicky

Lung cancer is the most deadly cancer disease (18 % of deaths are caused by cancer) (Sung et al., 2021). Cancer treatment is connected with severe side effects due to whole-body exposure to strong cytotoxic anticancer drugs (Zhang et al., 2018). Inhalation treatment could decrease the exposure of the healthy organs and eliminate the side effects. Liposomal carrier systems are a perspective option of inhalation delivery of anticancer drugs, because of their biocompatibility, the longer retention in the lung, or targeted cellular therapy (Young et al., 2015). The liposome from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) stabilized by cholesterol phosphatidic acid (PA) was nebulized by Pari LC Sprint Star nebulizer (Pari GmbH, Germany). MMAD (Mass Median Aerodynamic Diameter) of generated aerosol measured by Aerodynamic Particle Sizer (APS, TSI Inc., Minnesota) was 7.27±0.26 µm and GSD (Geometric Standard Deviation) was 1.54±0.01 µm. The deposition of a nebulized system in a replica of the huma

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

20303 - Thermodynamics

Projekt

<a href="/cs/project/GA20-27653S" target="_blank" >GA20-27653S: Vliv vývoje plic u novorozenců a dětí na charakteristiky proudění a depozici aerosolů – výpočtové modelování a experimentální validace</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů