INFLUENCE OF PC3-DERIVED EXOSOMES ON FIBROBLAST PROLIFERATION AND MIGRATION
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26220%2F23%3APU149324" target="_blank" >RIV/00216305:26220/23:PU149324 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/62156489:43210/24:43924927
Výsledek na webu
<a href="https://doi.org/10.37904/nanocon.2023.4802" target="_blank" >https://doi.org/10.37904/nanocon.2023.4802</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.37904/nanocon.2023.4802" target="_blank" >10.37904/nanocon.2023.4802</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
INFLUENCE OF PC3-DERIVED EXOSOMES ON FIBROBLAST PROLIFERATION AND MIGRATION
Popis výsledku v původním jazyce
Nano-sized exosomes are essential for intercellular communication, especially in cancer biology. Human produces exosomes that may modulate the tumor microenvironment and cellular behavior. This study examines how human prostate cancer cells (PC3) derived exosomes affect fibroblast proliferation and migration. Ultracentrifugation isolated exosomes from PC3 cell culture supernatants, which were characterized by confocal and transmission electron microscopy (TEM). Fibroblast cells were exposed to these PC3-derived exosomes. MTT [3–(4,5-dimethylthiazol-2yl)-2,5-diphenyl-2H-tetrazoliumbromide] was used to measure fibroblast proliferation, while another assay measured migration. PC3 exosomes appear to boost fibroblast proliferation and migration. Investigations into the molecular mechanisms behind these observations are ongoing. The study shows that PC3-derived exosomes can regulate fibroblast proliferation and migration. This study illuminates the effects of cancer cell-derived exosomes on cellular interactions and therapeutic potential.
Název v anglickém jazyce
INFLUENCE OF PC3-DERIVED EXOSOMES ON FIBROBLAST PROLIFERATION AND MIGRATION
Popis výsledku anglicky
Nano-sized exosomes are essential for intercellular communication, especially in cancer biology. Human produces exosomes that may modulate the tumor microenvironment and cellular behavior. This study examines how human prostate cancer cells (PC3) derived exosomes affect fibroblast proliferation and migration. Ultracentrifugation isolated exosomes from PC3 cell culture supernatants, which were characterized by confocal and transmission electron microscopy (TEM). Fibroblast cells were exposed to these PC3-derived exosomes. MTT [3–(4,5-dimethylthiazol-2yl)-2,5-diphenyl-2H-tetrazoliumbromide] was used to measure fibroblast proliferation, while another assay measured migration. PC3 exosomes appear to boost fibroblast proliferation and migration. Investigations into the molecular mechanisms behind these observations are ongoing. The study shows that PC3-derived exosomes can regulate fibroblast proliferation and migration. This study illuminates the effects of cancer cell-derived exosomes on cellular interactions and therapeutic potential.
Klasifikace
Druh
D - Stať ve sborníku
CEP obor
—
OECD FORD obor
10601 - Cell biology
Návaznosti výsledku
Projekt
—
Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2023
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název statě ve sborníku
CONFERENCE PROCEEDINGS - NANOCON 2023
ISBN
978-80-88365-15-0
ISSN
2694-930X
e-ISSN
—
Počet stran výsledku
5
Strana od-do
268-272
Název nakladatele
TANGER Ltd.
Místo vydání
Ostrava, Czech Republic
Místo konání akce
Brno, Czech Republic
Datum konání akce
18. 10. 2023
Typ akce podle státní příslušnosti
WRD - Celosvětová akce
Kód UT WoS článku
—