Combined Density- and Grid- Based Method for Clustering of Protein Substructures

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26230%2F09%3APU82584" target="_blank" >RIV/00216305:26230/09:PU82584 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Combined Density- and Grid- Based Method for Clustering of Protein Substructures

Popis výsledku v původním jazyce

Data mining techniques may reveal interesting knowledge in various datasets. The biological databases are enormously large and therefore, data mining techniques could be extremely helpful to extract the knowledge from them. In our study, we focused on data mining in PDB - Protein Data Bank. We used cluster analysis to identify the sequences that occur in limited number of structural conformations (sequence-structure fragments). This knowledge about protein fragments can be used in protein structure predictions. In this paper, we present a combined density- and grid-based method that we developed for clustering of protein structures. We also compare this method with a simple density-based clustering method that we used in the first part of our study toprove the existence of protein sequences that occur in more than one structural conformation but the number of its structural conformations is limited.

Název v anglickém jazyce

Combined Density- and Grid- Based Method for Clustering of Protein Substructures

Popis výsledku anglicky

Data mining techniques may reveal interesting knowledge in various datasets. The biological databases are enormously large and therefore, data mining techniques could be extremely helpful to extract the knowledge from them. In our study, we focused on data mining in PDB - Protein Data Bank. We used cluster analysis to identify the sequences that occur in limited number of structural conformations (sequence-structure fragments). This knowledge about protein fragments can be used in protein structure predictions. In this paper, we present a combined density- and grid-based method that we developed for clustering of protein structures. We also compare this method with a simple density-based clustering method that we used in the first part of our study toprove the existence of protein sequences that occur in more than one structural conformation but the number of its structural conformations is limited.

Druh

D - Stať ve sborníku

CEP obor

JC - Počítačový hardware a software

OECD FORD obor

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Projekt

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Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2009

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

ZNALOSTI 2009, Proceedings of the 8th annual conference

ISBN

978-80-227-3015-0

ISSN

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e-ISSN

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Počet stran výsledku

12

Strana od-do

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Název nakladatele

Vydavateľstvo STU

Místo vydání

Brno

Místo konání akce

Brno

Datum konání akce

4. 2. 2009

Typ akce podle státní příslušnosti

CST - Celostátní akce

Kód UT WoS článku

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