Hyaluronan-cetyltrimethylammonium bromide interactions in aqueous and physiological solution studied by fluorescence techniques

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F14%3APU113581" target="_blank" >RIV/00216305:26310/14:PU113581 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Hyaluronan-cetyltrimethylammonium bromide interactions in aqueous and physiological solution studied by fluorescence techniques

Popis výsledku v původním jazyce

The aim of this work was to study systems composed of negatively charged polyelectrolyte ? hyaluronan and positively charged surfactant ? cetyltrimethylammonium bromide (CTAB), which could be potential used for targeted drug delivery. Two concentration series was mixed ? in an aqueous solution and in 0.15 mol l-1 sodium chloride (simply physiological solution). In the series, the concentration of hyaluronan was constant and the concentration of CTAB (well below the critical micelle concentration in water solution) was increased. The interactions between these components were studied in terms of the formation of hydrophobic domains, which were important for solubilization of molecules of hydrophobic drugs. The intensity of fluorescence, steady-state anisotropy and lifetime of the samples were measured. Perylene was chosen as fluorescent probe due to its hydrophobicity. It was found that in aqueous solution, small hydrophobic domains linked to hyaluronan chains are formed. Then an increa

Název v anglickém jazyce

Hyaluronan-cetyltrimethylammonium bromide interactions in aqueous and physiological solution studied by fluorescence techniques

Popis výsledku anglicky

The aim of this work was to study systems composed of negatively charged polyelectrolyte ? hyaluronan and positively charged surfactant ? cetyltrimethylammonium bromide (CTAB), which could be potential used for targeted drug delivery. Two concentration series was mixed ? in an aqueous solution and in 0.15 mol l-1 sodium chloride (simply physiological solution). In the series, the concentration of hyaluronan was constant and the concentration of CTAB (well below the critical micelle concentration in water solution) was increased. The interactions between these components were studied in terms of the formation of hydrophobic domains, which were important for solubilization of molecules of hydrophobic drugs. The intensity of fluorescence, steady-state anisotropy and lifetime of the samples were measured. Perylene was chosen as fluorescent probe due to its hydrophobicity. It was found that in aqueous solution, small hydrophobic domains linked to hyaluronan chains are formed. Then an increa

Druh

D - Stať ve sborníku

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

—

Projekt

<a href="/cs/project/LD12068" target="_blank" >LD12068: Příprava koloidů hyaluronanu s micelárními agregáty pro nanomedicínské aplikace a charakterizace jejich vlastností</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Chemie je život 2014 - Sborník příspěvků

ISBN

978-80-214-5078-3

ISSN

—

e-ISSN

—

Počet stran výsledku

6

Strana od-do

229-234

Název nakladatele

Neuveden

Místo vydání

Brno

Místo konání akce

Purkyňova 118, 612 00 Brno

Datum konání akce

4. 12. 2014

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

—