CYTOTOXIC AND GENOTOXIC EFFECTS OF LIPOSOME PARTICLES WITH ENCAPSULATED NATURAL EXTRACTS

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F18%3APU140010" target="_blank" >RIV/00216305:26310/18:PU140010 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

CYTOTOXIC AND GENOTOXIC EFFECTS OF LIPOSOME PARTICLES WITH ENCAPSULATED NATURAL EXTRACTS

Popis výsledku v původním jazyce

Easy scale up of production led to an increase in cosmetic industry interest in lipid nanostructures. There are currently some liposome formulations on the market and the amount of these products will indoubtedly continue to grow. For this, detailed studies about their potential genotoxicity and cytotoxicity are neccesary. Presented work deals with preparation and characterization of liposome particles with aqueous and oil extracts of plant origin. The aim of this work was to observe cytotoxic and genotoxic effects of prepared liposomes. Total phenolics, flavonoids and antioxidant activity of plant extracts were determined using spectrophotometry as well as encapsulation efficiency. Stability of liposome particles was evaluated using zeta potential and size of liposomes was determined by dynamic light scattering. Potential genotoxic effects of liposomes were analysed using SOS Chromotest. Cytotoxicity of liposome particles was observed in human epidermal keratinocytes HEK (102-05a). Micro- and nanoparticles with encapsulated antioxidant and antimicrobial active compounds can enhance the effectiveness of cosmetics and pharmaceuticals. In this work, the potential use of liposome particles with natural plant extracts in appropriate concentration was proposed.

Název v anglickém jazyce

CYTOTOXIC AND GENOTOXIC EFFECTS OF LIPOSOME PARTICLES WITH ENCAPSULATED NATURAL EXTRACTS

Popis výsledku anglicky

Easy scale up of production led to an increase in cosmetic industry interest in lipid nanostructures. There are currently some liposome formulations on the market and the amount of these products will indoubtedly continue to grow. For this, detailed studies about their potential genotoxicity and cytotoxicity are neccesary. Presented work deals with preparation and characterization of liposome particles with aqueous and oil extracts of plant origin. The aim of this work was to observe cytotoxic and genotoxic effects of prepared liposomes. Total phenolics, flavonoids and antioxidant activity of plant extracts were determined using spectrophotometry as well as encapsulation efficiency. Stability of liposome particles was evaluated using zeta potential and size of liposomes was determined by dynamic light scattering. Potential genotoxic effects of liposomes were analysed using SOS Chromotest. Cytotoxicity of liposome particles was observed in human epidermal keratinocytes HEK (102-05a). Micro- and nanoparticles with encapsulated antioxidant and antimicrobial active compounds can enhance the effectiveness of cosmetics and pharmaceuticals. In this work, the potential use of liposome particles with natural plant extracts in appropriate concentration was proposed.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

21001 - Nano-materials (production and properties)

Projekt

<a href="/cs/project/LO1211" target="_blank" >LO1211: Centrum materiálového výzkumu na FCH VUT v Brně - udržitelnost a rozvoj</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings Paper, 10TH ANNIVERSARY INTERNATIONAL CONFERENCE ON NANOMATERIALS - RESEARCH & APPLICATION (NANOCON 2018 (R))

ISBN

978-80-87294-89-5

ISSN

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e-ISSN

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Počet stran výsledku

6

Strana od-do

739-744

Název nakladatele

Tanger, a.s.

Místo vydání

TANGER LTD, KELTICKOVA 62, SLEZSKA, OSTRAVA 710

Místo konání akce

Brno

Datum konání akce

17. 10. 2018

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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