THE USE OF BIOACTIVE COMPOUNDS AND THEIR ENCAPSULATION INTO LIPOSOMES TO INCREASE THE EFFECTIVENESS AND CONTROL RELEASE

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F19%3APU136131" target="_blank" >RIV/00216305:26310/19:PU136131 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

THE USE OF BIOACTIVE COMPOUNDS AND THEIR ENCAPSULATION INTO LIPOSOMES TO INCREASE THE EFFECTIVENESS AND CONTROL RELEASE

Popis výsledku v původním jazyce

Extracts from naturally occurred sources, such as plants or microorganisms, have been recently tested for their interesting properties that can be used in food or cosmetic industry. The aim of this work is to encapsulate microbial compounds, some plant extracts and also model hydrophilic and hydrophobic substances. Chosen components were encapsulated into liposomes. Particle size and distributions of liposomes were analyzed by dynamic light scattering and their stability by using zeta potential. Spectrophotometric methods were used to measure encapsulation efficiency and to characterize the chosen plant extracts by its amount of total polyphenols, flavonoids and antioxidant activity. Chosen samples were analyzed for their antimicrobial activity and cytotoxicity. Serratia marcescens, Escherichia coli as gram-negative bacterias, Micrococcus luteus as gram-positive bacteria and fungal strain (Candida glabrata) were used to test antimicrobial activity. Human keratinocytes and mouse melanoma cells were used to cytotoxicity determination. It has been proved that encapsulation techniques help slowly release the active compounds from plant extracts and transport them to targeted location. Antimicrobial effect was also seen before and after encapsulation into liposomes. Moreover, none of the extracts showed evidence of cytotoxicity.

Název v anglickém jazyce

THE USE OF BIOACTIVE COMPOUNDS AND THEIR ENCAPSULATION INTO LIPOSOMES TO INCREASE THE EFFECTIVENESS AND CONTROL RELEASE

Popis výsledku anglicky

Extracts from naturally occurred sources, such as plants or microorganisms, have been recently tested for their interesting properties that can be used in food or cosmetic industry. The aim of this work is to encapsulate microbial compounds, some plant extracts and also model hydrophilic and hydrophobic substances. Chosen components were encapsulated into liposomes. Particle size and distributions of liposomes were analyzed by dynamic light scattering and their stability by using zeta potential. Spectrophotometric methods were used to measure encapsulation efficiency and to characterize the chosen plant extracts by its amount of total polyphenols, flavonoids and antioxidant activity. Chosen samples were analyzed for their antimicrobial activity and cytotoxicity. Serratia marcescens, Escherichia coli as gram-negative bacterias, Micrococcus luteus as gram-positive bacteria and fungal strain (Candida glabrata) were used to test antimicrobial activity. Human keratinocytes and mouse melanoma cells were used to cytotoxicity determination. It has been proved that encapsulation techniques help slowly release the active compounds from plant extracts and transport them to targeted location. Antimicrobial effect was also seen before and after encapsulation into liposomes. Moreover, none of the extracts showed evidence of cytotoxicity.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

21001 - Nano-materials (production and properties)

Projekt

<a href="/cs/project/LO1211" target="_blank" >LO1211: Centrum materiálového výzkumu na FCH VUT v Brně - udržitelnost a rozvoj</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

NANOCON 2018, 10TH ANNIVERSARY INTERNATIONAL CONFERENCE ON NANOMATERIALS - RESEARCH & APPLICATION

ISBN

978-80-87294-89-5

ISSN

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e-ISSN

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Počet stran výsledku

6

Strana od-do

386-391

Název nakladatele

TANGER

Místo vydání

Ostrava, Czech republic

Místo konání akce

Brno

Datum konání akce

17. 10. 2018

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000513131900067