Micellar nanocarriers based on hydrophobical hyaluronan

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F19%3APU137523" target="_blank" >RIV/00216305:26310/19:PU137523 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

Micellar nanocarriers based on hydrophobical hyaluronan

Popis výsledku v původním jazyce

This work studies the properties of modified biopolymers for potential use in targeted drug delivery. Various samples of hydrophobically modified hyaluronan with different degree of substitution were selected. The critical aggregation concentration (CAC) of these samples was measured using fluorescence spectroscopy, wherein it was found that micelle formation occurs over a wide concentration region. Environment of 0.15 M NaCl causes the decrease of CAC only slightly or not at all. The results were confirmed by measuring the dynamic light scattering, which also showed an increase in the size of aggregates with an increasing concentration. One of the samples exhibited a double size distribution. Zeta potential measurements provide information about stability of the samples. The results of this study confirm that the studied samples seem to be a suitable candidates for the post of drug carrier for targeted delivery.

Název v anglickém jazyce

Micellar nanocarriers based on hydrophobical hyaluronan

Popis výsledku anglicky

This work studies the properties of modified biopolymers for potential use in targeted drug delivery. Various samples of hydrophobically modified hyaluronan with different degree of substitution were selected. The critical aggregation concentration (CAC) of these samples was measured using fluorescence spectroscopy, wherein it was found that micelle formation occurs over a wide concentration region. Environment of 0.15 M NaCl causes the decrease of CAC only slightly or not at all. The results were confirmed by measuring the dynamic light scattering, which also showed an increase in the size of aggregates with an increasing concentration. One of the samples exhibited a double size distribution. Zeta potential measurements provide information about stability of the samples. The results of this study confirm that the studied samples seem to be a suitable candidates for the post of drug carrier for targeted delivery.

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

<a href="/cs/project/LO1211" target="_blank" >LO1211: Centrum materiálového výzkumu na FCH VUT v Brně - udržitelnost a rozvoj</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů