Preparation and characterisation of functionalized wound dressings

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F20%3APU137920" target="_blank" >RIV/00216305:26310/20:PU137920 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.fch.vut.cz/vav/konference/sok/vystupy/sbornik-abstrakty-konference-2020-pdf-p198641" target="_blank" >https://www.fch.vut.cz/vav/konference/sok/vystupy/sbornik-abstrakty-konference-2020-pdf-p198641</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Preparation and characterisation of functionalized wound dressings

Popis výsledku v původním jazyce

This work is focused on preparation and characterization of bio-active hydrogels and nanofiber wound dressings functionalized by active compound in the form of antibiotic drug: ampicillin. Nano-fiber dressings were constituted from poly(3-hydroxybutyrate) and hydrogel dressings were created using alginate and chitosan. Prepared wound dressings were tested for possible cytotoxic ef-fects on human cells, antimicrobial activity and the rate of gradual releasing of the incorporated substance into model environments.Nanofibers were assembled by electrospinning and force spin-ning techniques. Morphology of the prepared nanofibers was con-firmed by SEM. Dressings were characterized for gradual release using spectrophotometric methods. Antimicrobial activity against gram-positive and gram-negative strains of microorganisms was also evaluated. the results showed good antimicrobial efficacy of functionalized materials.

Název v anglickém jazyce

Preparation and characterisation of functionalized wound dressings

Popis výsledku anglicky

This work is focused on preparation and characterization of bio-active hydrogels and nanofiber wound dressings functionalized by active compound in the form of antibiotic drug: ampicillin. Nano-fiber dressings were constituted from poly(3-hydroxybutyrate) and hydrogel dressings were created using alginate and chitosan. Prepared wound dressings were tested for possible cytotoxic ef-fects on human cells, antimicrobial activity and the rate of gradual releasing of the incorporated substance into model environments.Nanofibers were assembled by electrospinning and force spin-ning techniques. Morphology of the prepared nanofibers was con-firmed by SEM. Dressings were characterized for gradual release using spectrophotometric methods. Antimicrobial activity against gram-positive and gram-negative strains of microorganisms was also evaluated. the results showed good antimicrobial efficacy of functionalized materials.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30404 - Biomaterials (as related to medical implants, devices, sensors)

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů