CHARACTERIZATION OF NANOFIBER AND HYDROGEL WOUND DRESSINGS

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F21%3APU142563" target="_blank" >RIV/00216305:26310/21:PU142563 - isvavai.cz</a>

Výsledek na webu

—

DOI - Digital Object Identifier

—

Jazyk výsledku

angličtina

Název v původním jazyce

CHARACTERIZATION OF NANOFIBER AND HYDROGEL WOUND DRESSINGS

Popis výsledku v původním jazyce

The primary function of the wound dressings has been to clean, cover and protect the wound from external environment. They have been applied on injured areas to provide moist environment, protect the wound from infection, remove excess of exudate, avoid maceration and maintain sufficient exchange of gases. The aim of this study was to prepare and characterize bioactive hydrogel and nanofiber wound dressings functionalized by broad spectrum antibiotic drug, ampicillin. Nanostructures were constituted from poly(3- hydroxybutyrate) and hydrogels were alginate and chitosan based. Nanofibers were assembled by electrospinning and force spinning techniques and their morphology was confirmed by scanning electron microscopy. Prepared materials were analysed for gradual releasing of the incorporated substance into model environments using spectrophotometric methods. Antibacterial activity against model gram-positive (M. luteus) and gram-negative (S. epidermidis, E. coli) bacterial strains was also evaluated. Th

Název v anglickém jazyce

CHARACTERIZATION OF NANOFIBER AND HYDROGEL WOUND DRESSINGS

Popis výsledku anglicky

The primary function of the wound dressings has been to clean, cover and protect the wound from external environment. They have been applied on injured areas to provide moist environment, protect the wound from infection, remove excess of exudate, avoid maceration and maintain sufficient exchange of gases. The aim of this study was to prepare and characterize bioactive hydrogel and nanofiber wound dressings functionalized by broad spectrum antibiotic drug, ampicillin. Nanostructures were constituted from poly(3- hydroxybutyrate) and hydrogels were alginate and chitosan based. Nanofibers were assembled by electrospinning and force spinning techniques and their morphology was confirmed by scanning electron microscopy. Prepared materials were analysed for gradual releasing of the incorporated substance into model environments using spectrophotometric methods. Antibacterial activity against model gram-positive (M. luteus) and gram-negative (S. epidermidis, E. coli) bacterial strains was also evaluated. Th

Druh

O - Ostatní výsledky

CEP obor

—

OECD FORD obor

30404 - Biomaterials (as related to medical implants, devices, sensors)

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů