Functionalized nanofibers with immobilized liposome particles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F22%3APU146751" target="_blank" >RIV/00216305:26310/22:PU146751 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.icct.cz/cs/program/book-of-abstracts" target="_blank" >https://www.icct.cz/cs/program/book-of-abstracts</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Functionalized nanofibers with immobilized liposome particles

Popis výsledku v původním jazyce

Wound healing requires suitable environment to promote healing process. Therefore, treatment and management of wounds largely depends on the dressing material, that provides surface protection, drug delivery and allows tissue regeneration. Presented work is focused on preparation and further characterization of PHB nanofibers with immobilized PHB-liposome particles. Nanomaterials were functionalized by broad-spectrum antibiotic drug ampicillin. Combined nanostructures were prepared as novel potential wound dressings. Scanning electron microscopy and fluorescence microscopy were used to observe structure of prepared combined nanofiber-nanoparticle mats. Materials were further tested for the encapsulation efficiency and in vitro release of incorporated drug into model environment by spectrophotometric and chromatographic methods. Particle´s size and colloid stability was defined by dynamic light scattering and zeta-potential. The antimicrobial activity against selected strains of gram-positive and gram-

Název v anglickém jazyce

Functionalized nanofibers with immobilized liposome particles

Popis výsledku anglicky

Wound healing requires suitable environment to promote healing process. Therefore, treatment and management of wounds largely depends on the dressing material, that provides surface protection, drug delivery and allows tissue regeneration. Presented work is focused on preparation and further characterization of PHB nanofibers with immobilized PHB-liposome particles. Nanomaterials were functionalized by broad-spectrum antibiotic drug ampicillin. Combined nanostructures were prepared as novel potential wound dressings. Scanning electron microscopy and fluorescence microscopy were used to observe structure of prepared combined nanofiber-nanoparticle mats. Materials were further tested for the encapsulation efficiency and in vitro release of incorporated drug into model environment by spectrophotometric and chromatographic methods. Particle´s size and colloid stability was defined by dynamic light scattering and zeta-potential. The antimicrobial activity against selected strains of gram-positive and gram-

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

21001 - Nano-materials (production and properties)

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů