Dried blood spot self‐sampling with automated capillary electrophoresis processing for clinical analysis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F20%3APU138117" target="_blank" >RIV/00216305:26310/20:PU138117 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1002/anie.202012997" target="_blank" >https://doi.org/10.1002/anie.202012997</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/ange.202012997" target="_blank" >10.1002/ange.202012997</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dried blood spot self‐sampling with automated capillary electrophoresis processing for clinical analysis

Popis výsledku v původním jazyce

A simple and convenient concept of blood sampling followed by a fully automated analysis is presented. A disposable sampling kit is used for accurate self‐sampling of capillary blood from a finger prick. A high throughput blood sampling is thus enabled, which is essential in many clinical assays and considerably improves life quality and comfort of involved subjects. The collected blood samples are mailed to a laboratory for a fully automated dried blood spot (DBS) processing and analysis, which are performed with a commercial capillary electrophoresis instrument. Quantitative results are obtained within 20 min from the DBS delivery to the laboratory. The presented concept is exemplified by the determination of warfarin blood concentrations and demonstrates excellent analytical performance. Moreover, this concept is generally applicable to a wide range of endogenous and exogenous blood compounds and represents a novel and attractive analytical tool for personalized human health monitoring.

Název v anglickém jazyce

Dried blood spot self‐sampling with automated capillary electrophoresis processing for clinical analysis

Popis výsledku anglicky

A simple and convenient concept of blood sampling followed by a fully automated analysis is presented. A disposable sampling kit is used for accurate self‐sampling of capillary blood from a finger prick. A high throughput blood sampling is thus enabled, which is essential in many clinical assays and considerably improves life quality and comfort of involved subjects. The collected blood samples are mailed to a laboratory for a fully automated dried blood spot (DBS) processing and analysis, which are performed with a commercial capillary electrophoresis instrument. Quantitative results are obtained within 20 min from the DBS delivery to the laboratory. The presented concept is exemplified by the determination of warfarin blood concentrations and demonstrates excellent analytical performance. Moreover, this concept is generally applicable to a wide range of endogenous and exogenous blood compounds and represents a novel and attractive analytical tool for personalized human health monitoring.

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

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OECD FORD obor

10406 - Analytical chemistry

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Angewandte Chemie

ISSN

0044-8249

e-ISSN

1521-3757

Svazek periodika

132

Číslo periodika v rámci svazku

51

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

7

Strana od-do

7171-7178

Kód UT WoS článku

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EID výsledku v databázi Scopus

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