Dried Blood Spot Self-Sampling with Automated Capillary Electrophoresis Processing for Clinical Analysis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26310%2F21%3APU147694" target="_blank" >RIV/00216305:26310/21:PU147694 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216305:26310/21:PU140137 RIV/68081715:_____/21:00539864

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/full/10.1002/anie.202012997" target="_blank" >https://onlinelibrary.wiley.com/doi/full/10.1002/anie.202012997</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/anie.202012997" target="_blank" >10.1002/anie.202012997</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dried Blood Spot Self-Sampling with Automated Capillary Electrophoresis Processing for Clinical Analysis

Popis výsledku v původním jazyce

A simple and convenient concept of blood sampling followed by a fully automated analysis is presented. A disposable sampling kit is used for accurate self-sampling of capillary blood from a finger prick. A high-throughput blood sampling is thus enabled, which is essential in many clinical assays and considerably improves life quality and comfort of involved subjects. The collected blood samples are mailed to a laboratory for a fully automated dried blood spot (DBS) processing and analysis, which are performed with a commercial capillary electrophoresis instrument. Quantitative results are obtained within 20 min from the DBS delivery to the laboratory. The presented concept is exemplified by the determination of warfarin blood concentrations and demonstrates excellent analytical performance. Moreover, this concept is generally applicable to a wide range of endogenous and exogenous blood compounds and represents a novel and attractive analytical tool for personalized health monitoring.

Název v anglickém jazyce

Dried Blood Spot Self-Sampling with Automated Capillary Electrophoresis Processing for Clinical Analysis

Popis výsledku anglicky

A simple and convenient concept of blood sampling followed by a fully automated analysis is presented. A disposable sampling kit is used for accurate self-sampling of capillary blood from a finger prick. A high-throughput blood sampling is thus enabled, which is essential in many clinical assays and considerably improves life quality and comfort of involved subjects. The collected blood samples are mailed to a laboratory for a fully automated dried blood spot (DBS) processing and analysis, which are performed with a commercial capillary electrophoresis instrument. Quantitative results are obtained within 20 min from the DBS delivery to the laboratory. The presented concept is exemplified by the determination of warfarin blood concentrations and demonstrates excellent analytical performance. Moreover, this concept is generally applicable to a wide range of endogenous and exogenous blood compounds and represents a novel and attractive analytical tool for personalized health monitoring.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10400 - Chemical sciences

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

ISSN

1433-7851

e-ISSN

1521-3773

Svazek periodika

60

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

8

Strana od-do

6068-6075

Kód UT WoS článku

000613441700001

EID výsledku v databázi Scopus

2-s2.0-85100255896