Dinuclear half-sandwich Ir(III) complexes containing 4,4 '-methylenedianiline-based ligands: Synthesis, characterization, cytotoxicity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F21%3APU140632" target="_blank" >RIV/00216305:26620/21:PU140632 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15310/21:73609421

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0022328X21000693?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0022328X21000693?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jorganchem.2021.121748" target="_blank" >10.1016/j.jorganchem.2021.121748</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dinuclear half-sandwich Ir(III) complexes containing 4,4 '-methylenedianiline-based ligands: Synthesis, characterization, cytotoxicity

Popis výsledku v původním jazyce

Three dinuclear half-sandwich iridium(III) complexes [Ir-2(mu-L1)(eta(5)-Cp*)(2)Cl-2](PF6)2 (1), [Ir-2(mu-L2)(eta(5)-Cp*)(2)Cl-2](PF6)(2) (2) and [Ir-2(mu-L3)(eta(5)-Cp*)(2)Cl-2](PF6)(2) (3) with tetradentate 4,4'-methylenedianiline-based N-donor ligands (L1-L3) were prepared and characterized by NMR spectroscopy, elemental analysis, mass spectrometry and FTIR spectroscopy. Complex 3 was hydrolytically less stable in 20% DMSO-d(6)/80% D2O than 1 and 2, while all the studied complexes were stable in the same mixture of solvents in the presence of PBS (pH 7.4). In addition, complexes 1-3 converted coenzyme NADH to its oxidized form (NAD(+)). Cytotoxicity of 1-3 was evaluated on five human cancer cell lines, in particular lung carcinoma (A549), hepatocellular carcinoma (HepG2), melanoma (A375), prostate carcinoma (DU-145) and breast carcinoma (MCF-7). The best-performing complex 2 showed comparable cytotoxicity to conventional cisplatin against the A549 and HepG2 cell lines. (C) 2021 Elsevier B.V. All rights reserved.

Název v anglickém jazyce

Dinuclear half-sandwich Ir(III) complexes containing 4,4 '-methylenedianiline-based ligands: Synthesis, characterization, cytotoxicity

Popis výsledku anglicky

Three dinuclear half-sandwich iridium(III) complexes [Ir-2(mu-L1)(eta(5)-Cp*)(2)Cl-2](PF6)2 (1), [Ir-2(mu-L2)(eta(5)-Cp*)(2)Cl-2](PF6)(2) (2) and [Ir-2(mu-L3)(eta(5)-Cp*)(2)Cl-2](PF6)(2) (3) with tetradentate 4,4'-methylenedianiline-based N-donor ligands (L1-L3) were prepared and characterized by NMR spectroscopy, elemental analysis, mass spectrometry and FTIR spectroscopy. Complex 3 was hydrolytically less stable in 20% DMSO-d(6)/80% D2O than 1 and 2, while all the studied complexes were stable in the same mixture of solvents in the presence of PBS (pH 7.4). In addition, complexes 1-3 converted coenzyme NADH to its oxidized form (NAD(+)). Cytotoxicity of 1-3 was evaluated on five human cancer cell lines, in particular lung carcinoma (A549), hepatocellular carcinoma (HepG2), melanoma (A375), prostate carcinoma (DU-145) and breast carcinoma (MCF-7). The best-performing complex 2 showed comparable cytotoxicity to conventional cisplatin against the A549 and HepG2 cell lines. (C) 2021 Elsevier B.V. All rights reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

<a href="/cs/project/LQ1601" target="_blank" >LQ1601: CEITEC 2020</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JOURNAL OF ORGANOMETALLIC CHEMISTRY

ISSN

0022-328X

e-ISSN

1872-8561

Svazek periodika

938

Číslo periodika v rámci svazku

2021-04-15

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

7

Strana od-do

121748-121755

Kód UT WoS článku

000632247300004

EID výsledku v databázi Scopus

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