New Pt(II) diiodido complexes containing bidentate 1,3,4-thiadiazole-based ligands: Synthesis, characterization, cytotoxicity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F22%3A73615121" target="_blank" >RIV/61989592:15310/22:73615121 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0020169322001037" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0020169322001037</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ica.2022.120891" target="_blank" >10.1016/j.ica.2022.120891</a>

Jazyk výsledku

angličtina

Název v původním jazyce

New Pt(II) diiodido complexes containing bidentate 1,3,4-thiadiazole-based ligands: Synthesis, characterization, cytotoxicity

Popis výsledku v původním jazyce

Two diiodidoplatinum(II) complexes [PtI2(L1)1 (1) and [PtI2(L2)] (2) with isomeric bidentate 1,3,4-thiadiazole-based N-donor ligands (L1, L2) were prepared and characterized by multinuclear NMR spectroscopy, elemental analysis, infrared spectroscopy and mass spectrometry. Complexes 1 and 2 were hydrolytically stable in 50% DMF-d(7)/50% D2O and 50% DMF-d(7)/50% PBS in D2O (pH 7.4). Cytotoxicity of 1 and 2 was evaluated on five human cancer cell lines, i.e. lung carcinoma (A549), hepatocellular carcinoma (HepG2), melanoma (A375), prostate carcinoma (DU-145) and breast carcinoma (MCF-7). Only the HepG2 (IC50 = 22.0 and 17.8 mu M for 1 and 2, respectively) and A549 (IC50 = 18.5 mu M for 1) cells were sensitive to the studied complexes, but their in vitro cytotoxicity was slightly lower than determined for the reference drug cisplatin (IC50 = 12.0 and 12.3 mu M at the HepG2 and A549 cells, respectively). Both complexes 1 and 2 effectively quenched the fluorescence of the EtBr-DNA system (EtBr = ethidium bromide) but did not interact covalently with guanosine monophosphate used as a model DNA molecule.

Název v anglickém jazyce

New Pt(II) diiodido complexes containing bidentate 1,3,4-thiadiazole-based ligands: Synthesis, characterization, cytotoxicity

Popis výsledku anglicky

Two diiodidoplatinum(II) complexes [PtI2(L1)1 (1) and [PtI2(L2)] (2) with isomeric bidentate 1,3,4-thiadiazole-based N-donor ligands (L1, L2) were prepared and characterized by multinuclear NMR spectroscopy, elemental analysis, infrared spectroscopy and mass spectrometry. Complexes 1 and 2 were hydrolytically stable in 50% DMF-d(7)/50% D2O and 50% DMF-d(7)/50% PBS in D2O (pH 7.4). Cytotoxicity of 1 and 2 was evaluated on five human cancer cell lines, i.e. lung carcinoma (A549), hepatocellular carcinoma (HepG2), melanoma (A375), prostate carcinoma (DU-145) and breast carcinoma (MCF-7). Only the HepG2 (IC50 = 22.0 and 17.8 mu M for 1 and 2, respectively) and A549 (IC50 = 18.5 mu M for 1) cells were sensitive to the studied complexes, but their in vitro cytotoxicity was slightly lower than determined for the reference drug cisplatin (IC50 = 12.0 and 12.3 mu M at the HepG2 and A549 cells, respectively). Both complexes 1 and 2 effectively quenched the fluorescence of the EtBr-DNA system (EtBr = ethidium bromide) but did not interact covalently with guanosine monophosphate used as a model DNA molecule.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

INORGANICA CHIMICA ACTA

ISSN

0020-1693

e-ISSN

1873-3255

Svazek periodika

536

Číslo periodika v rámci svazku

JUN

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

"120891-1"-"120891-8"

Kód UT WoS článku

000866440700001

EID výsledku v databázi Scopus

2-s2.0-85126288790