Dinuclear half-sandwich Ir(III) complexes containing 4,4 '-methylenedianiline-based ligands: Synthesis, characterization, cytotoxicity

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F21%3A73609421" target="_blank" >RIV/61989592:15310/21:73609421 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216305:26620/21:PU140632

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0022328X21000693" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0022328X21000693</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jorganchem.2021.121748" target="_blank" >10.1016/j.jorganchem.2021.121748</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Dinuclear half-sandwich Ir(III) complexes containing 4,4 '-methylenedianiline-based ligands: Synthesis, characterization, cytotoxicity

Popis výsledku v původním jazyce

Three dinuclear half-sandwich iridium(III) complexes [Ir-2(mu-L1)(eta(5)-Cp*)(2)Cl-2](PF6)2 (1), [Ir-2(mu-L2)(eta(5)-Cp*)(2)Cl-2](PF6)(2) (2) and [Ir-2(mu-L3)(eta(5)-Cp*)(2)Cl-2](PF6)(2) (3) with tetradentate 4,4&apos;-methylenedianiline-based N-donor ligands (L1-L3) were prepared and characterized by NMR spectroscopy, elemental analysis, mass spectrometry and FTIR spectroscopy. Complex 3 was hydrolytically less stable in 20% DMSO-d(6)/80% D2O than 1 and 2, while all the studied complexes were stable in the same mixture of solvents in the presence of PBS (pH 7.4). In addition, complexes 1-3 converted coenzyme NADH to its oxidized form (NAD(+)). Cytotoxicity of 1-3 was evaluated on five human cancer cell lines, in particular lung carcinoma (A549), hepatocellular carcinoma (HepG2), melanoma (A375), prostate carcinoma (DU-145) and breast carcinoma (MCF-7). The best-performing complex 2 showed comparable cytotoxicity to conventional cisplatin against the A549 and HepG2 cell lines.

Název v anglickém jazyce

Dinuclear half-sandwich Ir(III) complexes containing 4,4 '-methylenedianiline-based ligands: Synthesis, characterization, cytotoxicity

Popis výsledku anglicky

Three dinuclear half-sandwich iridium(III) complexes [Ir-2(mu-L1)(eta(5)-Cp*)(2)Cl-2](PF6)2 (1), [Ir-2(mu-L2)(eta(5)-Cp*)(2)Cl-2](PF6)(2) (2) and [Ir-2(mu-L3)(eta(5)-Cp*)(2)Cl-2](PF6)(2) (3) with tetradentate 4,4&apos;-methylenedianiline-based N-donor ligands (L1-L3) were prepared and characterized by NMR spectroscopy, elemental analysis, mass spectrometry and FTIR spectroscopy. Complex 3 was hydrolytically less stable in 20% DMSO-d(6)/80% D2O than 1 and 2, while all the studied complexes were stable in the same mixture of solvents in the presence of PBS (pH 7.4). In addition, complexes 1-3 converted coenzyme NADH to its oxidized form (NAD(+)). Cytotoxicity of 1-3 was evaluated on five human cancer cell lines, in particular lung carcinoma (A549), hepatocellular carcinoma (HepG2), melanoma (A375), prostate carcinoma (DU-145) and breast carcinoma (MCF-7). The best-performing complex 2 showed comparable cytotoxicity to conventional cisplatin against the A549 and HepG2 cell lines.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10402 - Inorganic and nuclear chemistry

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JOURNAL OF ORGANOMETALLIC CHEMISTRY

ISSN

0022-328X

e-ISSN

—

Svazek periodika

938

Číslo periodika v rámci svazku

APR

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

7

Strana od-do

"121748-1"-"121748-7"

Kód UT WoS článku

000632247300004

EID výsledku v databázi Scopus

2-s2.0-85101135170