MWCNTs-supported Ni electrocatalyst-modified CPE as a sensing platform for voltammetric determination of ibuprofen in pharmaceutical formulations

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216305%3A26620%2F24%3APU151583" target="_blank" >RIV/00216305:26620/24:PU151583 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/62156489:43210/24:43924884

Výsledek na webu

<a href="https://link.springer.com/article/10.1007/s00706-023-03158-0" target="_blank" >https://link.springer.com/article/10.1007/s00706-023-03158-0</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1007/s00706-023-03158-0" target="_blank" >10.1007/s00706-023-03158-0</a>

Jazyk výsledku

angličtina

Název v původním jazyce

MWCNTs-supported Ni electrocatalyst-modified CPE as a sensing platform for voltammetric determination of ibuprofen in pharmaceutical formulations

Popis výsledku v původním jazyce

In this work, a sensitive and reproducible voltammetric methodology using a modified carbon paste electrode has been established for the determination of the non-steroidal anti-inflammatory drug ibuprofen. MWCNTs-supported Ni electrocatalyst was applied as a bulk carbon paste modifier to fabricate the Ni-MWCNTs-CPE sensor, while square-wave voltammetry was utilized as an electroanalytical technique. Besides, cyclic voltammetry was used to study the electrochemical behavior of ibuprofen on the proposed sensor. Parameters of square-wave voltammetry were optimized using acetate buffer pH 4.5 as an optimal electrolyte. In addition, the sensitivity of the modified carbon paste electrode, as a sensing element, was compared to the unmodified one. Under optimized conditions, a wide linear range was obtained with LOD and LOQ values of 0.86 and 2.61 mu M, and 0.13 and 0.39 mu M, for bare CPE and Ni-MWCNTs-CPE, respectively. The presence of the modifier in the paste improved the sensitivity of the carbon paste electrode by almost 7 times. In addition, the newly fabricated Ni-MWCNTs-CPE sensor showed better results in terms of precision (RSD up to 2.49%). Finally, the validated voltammetric methodology was successfully applied for the determination of ibuprofen content in pharmaceutical formulations, without any complicated preliminary preparation steps, with recovery values between 94.4 and 98.1%.

Název v anglickém jazyce

MWCNTs-supported Ni electrocatalyst-modified CPE as a sensing platform for voltammetric determination of ibuprofen in pharmaceutical formulations

Popis výsledku anglicky

In this work, a sensitive and reproducible voltammetric methodology using a modified carbon paste electrode has been established for the determination of the non-steroidal anti-inflammatory drug ibuprofen. MWCNTs-supported Ni electrocatalyst was applied as a bulk carbon paste modifier to fabricate the Ni-MWCNTs-CPE sensor, while square-wave voltammetry was utilized as an electroanalytical technique. Besides, cyclic voltammetry was used to study the electrochemical behavior of ibuprofen on the proposed sensor. Parameters of square-wave voltammetry were optimized using acetate buffer pH 4.5 as an optimal electrolyte. In addition, the sensitivity of the modified carbon paste electrode, as a sensing element, was compared to the unmodified one. Under optimized conditions, a wide linear range was obtained with LOD and LOQ values of 0.86 and 2.61 mu M, and 0.13 and 0.39 mu M, for bare CPE and Ni-MWCNTs-CPE, respectively. The presence of the modifier in the paste improved the sensitivity of the carbon paste electrode by almost 7 times. In addition, the newly fabricated Ni-MWCNTs-CPE sensor showed better results in terms of precision (RSD up to 2.49%). Finally, the validated voltammetric methodology was successfully applied for the determination of ibuprofen content in pharmaceutical formulations, without any complicated preliminary preparation steps, with recovery values between 94.4 and 98.1%.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Monatshefte für Chemie

ISSN

0026-9247

e-ISSN

1434-4475

Svazek periodika

155

Číslo periodika v rámci svazku

3-4

Stát vydavatele periodika

AT - Rakouská republika

Počet stran výsledku

9

Strana od-do

289-297

Kód UT WoS článku

001163646800001

EID výsledku v databázi Scopus

2-s2.0-85185116427