Influence of physiological and supraphysiological hyperinsulinemia on skin microcirculation in healthy volunteers

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00669806%3A_____%2F13%3A10145795" target="_blank" >RIV/00669806:_____/13:10145795 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874498/pdf/WJD-4-372.pdf" target="_blank" >http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874498/pdf/WJD-4-372.pdf</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.4239/wjd.v4.i6.372" target="_blank" >10.4239/wjd.v4.i6.372</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Influence of physiological and supraphysiological hyperinsulinemia on skin microcirculation in healthy volunteers

Popis výsledku v původním jazyce

AIM To examine skin perfusion in dependency on insulinemia in healthy subjects. METHODS: All volunteers were informed in detail about the procedures and signed informed consent. The protocol of this study was approved by ethical committee. In our study atwo-stage hyperinsulinemic euglycaemic clamp was performed, with insulinemia 100 and 250 mIU/mL and glycaemia 5.0 mmol/L (3% standard deviation). Before the clamp and in steady states, microcirculation was measured by laser-doppler flowmetry and transcutaneous oximetry and energy expenditure was measured by indirect calorimetry. Results (average and standard deviation) were evaluated with paired t-test. RESULTS: Physiological (50 mIU/L) insulinemia leaded to higher perfusion in both tests- hyperemia after heating to 44 oC- 1848% (984 - 2046) vs 1599% (801 - 1836), P < 0.05, half time of reaching peak perfusion after occlusion release 1.2 s (0.9 - 2.6) vs 4.9 s (1.8 - 11.4), P < 0.05. Supraphysiological (150 mIU/L) insulinemia leaded to

Název v anglickém jazyce

Influence of physiological and supraphysiological hyperinsulinemia on skin microcirculation in healthy volunteers

Popis výsledku anglicky

AIM To examine skin perfusion in dependency on insulinemia in healthy subjects. METHODS: All volunteers were informed in detail about the procedures and signed informed consent. The protocol of this study was approved by ethical committee. In our study atwo-stage hyperinsulinemic euglycaemic clamp was performed, with insulinemia 100 and 250 mIU/mL and glycaemia 5.0 mmol/L (3% standard deviation). Before the clamp and in steady states, microcirculation was measured by laser-doppler flowmetry and transcutaneous oximetry and energy expenditure was measured by indirect calorimetry. Results (average and standard deviation) were evaluated with paired t-test. RESULTS: Physiological (50 mIU/L) insulinemia leaded to higher perfusion in both tests- hyperemia after heating to 44 oC- 1848% (984 - 2046) vs 1599% (801 - 1836), P < 0.05, half time of reaching peak perfusion after occlusion release 1.2 s (0.9 - 2.6) vs 4.9 s (1.8 - 11.4), P < 0.05. Supraphysiological (150 mIU/L) insulinemia leaded to

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FB - Endokrinologie, diabetologie, metabolismus, výživa

OECD FORD obor

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Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

World Journal of Diabetes

ISSN

1948-9358

e-ISSN

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Svazek periodika

4

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

CN - Čínská lidová republika

Počet stran výsledku

6

Strana od-do

372-377

Kód UT WoS článku

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EID výsledku v databázi Scopus

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