The APOE epsilon 2 allele is associated with increased plasma apolipoprotein E levels in patients with coronary artery disease

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00843989%3A_____%2F17%3AE0106711" target="_blank" >RIV/00843989:_____/17:E0106711 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61988987:17110/17:A1901ZFU

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.crvasa.2016.11.011" target="_blank" >http://dx.doi.org/10.1016/j.crvasa.2016.11.011</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.crvasa.2016.11.011" target="_blank" >10.1016/j.crvasa.2016.11.011</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The APOE epsilon 2 allele is associated with increased plasma apolipoprotein E levels in patients with coronary artery disease

Popis výsledku v původním jazyce

Aims: We sought to evaluate the influence of APOE polymorphisms (epsilon 2-rs7412, epsilon 4-rs429358) on plasma levels of apolipoprotein E in patients with confirmed coronary artery disease. Methods: A total of 94 patients with coronary artery disease were included in our study. Genotypisation for rs429358 and rs7412 in APOE was performed and plasma levels of apolipoprotein E, lipids, and hs-CRP were measured. Results: Significantly higher plasma levels of APOE were found in the epsilon 2 carriers compared to the normal epsilon 3/epsilon 3 genotype (40.4 mg/mL vs. 22.9 mg/mL, P = 0.018). There was no difference in APOE levels between the epsilon 4 allele and epsilon 3/epsilon 3 allele carriers. Significantly higher HDL cholesterol levels (1.55 mmol/L vs. 1.16 mmol/L, P = 0.001) were found in the epsilon 2 carriers, and significantly lower levels of hs-CRP (1.07 mg/L vs. 2.14 mg/L, P = 0.035) in the epsilon 4 carriers compared to the normal epsilon 3/epsilon 3 genotype. Conclusions: In CAD patients, the epsilon 2 APOE allele is associated with significantly higher plasma levels of APOE and HDL cholesterol, whereas the epsilon 4 allele is associated with significantly lower levels of hsCRP.

Název v anglickém jazyce

The APOE epsilon 2 allele is associated with increased plasma apolipoprotein E levels in patients with coronary artery disease

Popis výsledku anglicky

Aims: We sought to evaluate the influence of APOE polymorphisms (epsilon 2-rs7412, epsilon 4-rs429358) on plasma levels of apolipoprotein E in patients with confirmed coronary artery disease. Methods: A total of 94 patients with coronary artery disease were included in our study. Genotypisation for rs429358 and rs7412 in APOE was performed and plasma levels of apolipoprotein E, lipids, and hs-CRP were measured. Results: Significantly higher plasma levels of APOE were found in the epsilon 2 carriers compared to the normal epsilon 3/epsilon 3 genotype (40.4 mg/mL vs. 22.9 mg/mL, P = 0.018). There was no difference in APOE levels between the epsilon 4 allele and epsilon 3/epsilon 3 allele carriers. Significantly higher HDL cholesterol levels (1.55 mmol/L vs. 1.16 mmol/L, P = 0.001) were found in the epsilon 2 carriers, and significantly lower levels of hs-CRP (1.07 mg/L vs. 2.14 mg/L, P = 0.035) in the epsilon 4 carriers compared to the normal epsilon 3/epsilon 3 genotype. Conclusions: In CAD patients, the epsilon 2 APOE allele is associated with significantly higher plasma levels of APOE and HDL cholesterol, whereas the epsilon 4 allele is associated with significantly lower levels of hsCRP.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30201 - Cardiac and Cardiovascular systems

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Cor et Vasa

ISSN

0010-8650

e-ISSN

1803-7712

Svazek periodika

59

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

PL - Polská republika

Počet stran výsledku

1

Strana od-do

e235-e239

Kód UT WoS článku

000410032200004

EID výsledku v databázi Scopus

2-s2.0-85008487957