The APOE epsilon 2 allele is associated with increased plasma apolipoprotein E levels in patients with coronary artery disease
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61988987%3A17110%2F17%3AA1901ZFU" target="_blank" >RIV/61988987:17110/17:A1901ZFU - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/00843989:_____/17:E0106711
Výsledek na webu
<a href="http://dx.doi.org/10.1016/j.crvasa.2016.11.011" target="_blank" >http://dx.doi.org/10.1016/j.crvasa.2016.11.011</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.crvasa.2016.11.011" target="_blank" >10.1016/j.crvasa.2016.11.011</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The APOE epsilon 2 allele is associated with increased plasma apolipoprotein E levels in patients with coronary artery disease
Popis výsledku v původním jazyce
We sought to evaluate the influence of APOE polymorphisms (epsilon 2-rs7412, epsilon 4-rs429358) on plasma levels of apolipoprotein E in patients with confirmed coronary artery disease. A total of 94 patients with coronary artery disease were included in our study. Genotypisation for rs429358 and rs7412 in APOE was performed and plasma levels of apolipoprotein E, lipids, and hs-CRP were measured. Significantly higher plasma levels of APOE were found in the epsilon 2 carriers compared to the normal epsilon 3/epsilon 3 genotype (40.4 mg/mL vs. 22.9 mg/mL, P = 0.018). There was no difference in APOE levels between the epsilon 4 allele and epsilon 3/epsilon 3 allele carriers. Significantly higher HDL cholesterol levels (1.55 mmol/L vs. 1.16 mmol/L, P = 0.001) were found in the epsilon 2 carriers, and significantly lower levels of hs-CRP (1.07 mg/L vs. 2.14 mg/L, P = 0.035) in the epsilon 4 carriers compared to the normal epsilon 3/epsilon 3 genotype. In CAD patients, the epsilon 2 APOE allele is associated with significantly higher plasma levels of APOE and HDL cholesterol, whereas the epsilon 4 allele is associated with significantly lower levels of hsCRP.
Název v anglickém jazyce
The APOE epsilon 2 allele is associated with increased plasma apolipoprotein E levels in patients with coronary artery disease
Popis výsledku anglicky
We sought to evaluate the influence of APOE polymorphisms (epsilon 2-rs7412, epsilon 4-rs429358) on plasma levels of apolipoprotein E in patients with confirmed coronary artery disease. A total of 94 patients with coronary artery disease were included in our study. Genotypisation for rs429358 and rs7412 in APOE was performed and plasma levels of apolipoprotein E, lipids, and hs-CRP were measured. Significantly higher plasma levels of APOE were found in the epsilon 2 carriers compared to the normal epsilon 3/epsilon 3 genotype (40.4 mg/mL vs. 22.9 mg/mL, P = 0.018). There was no difference in APOE levels between the epsilon 4 allele and epsilon 3/epsilon 3 allele carriers. Significantly higher HDL cholesterol levels (1.55 mmol/L vs. 1.16 mmol/L, P = 0.001) were found in the epsilon 2 carriers, and significantly lower levels of hs-CRP (1.07 mg/L vs. 2.14 mg/L, P = 0.035) in the epsilon 4 carriers compared to the normal epsilon 3/epsilon 3 genotype. In CAD patients, the epsilon 2 APOE allele is associated with significantly higher plasma levels of APOE and HDL cholesterol, whereas the epsilon 4 allele is associated with significantly lower levels of hsCRP.
Klasifikace
Druh
J<sub>imp</sub> - Článek v periodiku v databázi Web of Science
CEP obor
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OECD FORD obor
30201 - Cardiac and Cardiovascular systems
Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2017
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
COR ET VASA
ISSN
0010-8650
e-ISSN
1803-7712
Svazek periodika
59
Číslo periodika v rámci svazku
3
Stát vydavatele periodika
NL - Nizozemsko
Počet stran výsledku
5
Strana od-do
235-239
Kód UT WoS článku
000410032200004
EID výsledku v databázi Scopus
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