Determination of Fetomaternal Hemorrhage by Flow Cytometry and Red Blood Cell Alloimmunization in Pregnancy

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Determination of Fetomaternal Hemorrhage by Flow Cytometry and Red Blood Cell Alloimmunization in Pregnancy

Popis výsledku v původním jazyce

Background and Objectives: The aim of the study was the quantitative determination of Fetomaternal Haemorrhage (FMH) by flow cytometry and Red Blood Cell (RBC) antibody identification in pregnancy. Materials and Methods: We present data from a prospective study of 94 women undergoing obstetric interventions from 12/2013 to 07/2014. FMH by flow cytometry using Anti-HbF, RBC antibody screening and ABO/RhD blood group by serology was determined in peripheral blood anticoagulated blood samples. The RBC antibody screening was repeated six weeks or later in 51 women. Results: Clinically significant FMH was founded in 9 cases of 94. We present 2 cases of excessive FMH. The first case was a spontaneous vaginal delivery at 40th week of pregnancy with a 4.9% FMH. The second case was acute caesarean section at 40th week of pregnancy with a 6.9% FMH. 8 from 94 samples contained RBC antibodies within the first examination immediately after obstetric procedure. 11 from 51 samples contained RBC antibodies within the second examination. Conclusion: FMH with possible clinical significance was founded in 9 cases, excessive FMH only twice. We proved the presence of clinically significant and less significant antibodies caused by FMH after the actual or previous pregnancy.

Název v anglickém jazyce

Determination of Fetomaternal Hemorrhage by Flow Cytometry and Red Blood Cell Alloimmunization in Pregnancy

Popis výsledku anglicky

Background and Objectives: The aim of the study was the quantitative determination of Fetomaternal Haemorrhage (FMH) by flow cytometry and Red Blood Cell (RBC) antibody identification in pregnancy. Materials and Methods: We present data from a prospective study of 94 women undergoing obstetric interventions from 12/2013 to 07/2014. FMH by flow cytometry using Anti-HbF, RBC antibody screening and ABO/RhD blood group by serology was determined in peripheral blood anticoagulated blood samples. The RBC antibody screening was repeated six weeks or later in 51 women. Results: Clinically significant FMH was founded in 9 cases of 94. We present 2 cases of excessive FMH. The first case was a spontaneous vaginal delivery at 40th week of pregnancy with a 4.9% FMH. The second case was acute caesarean section at 40th week of pregnancy with a 6.9% FMH. 8 from 94 samples contained RBC antibodies within the first examination immediately after obstetric procedure. 11 from 51 samples contained RBC antibodies within the second examination. Conclusion: FMH with possible clinical significance was founded in 9 cases, excessive FMH only twice. We proved the presence of clinically significant and less significant antibodies caused by FMH after the actual or previous pregnancy.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

30230 - Other clinical medicine subjects

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů