Determination of Fetomaternal Hemorrhage by Flow Cytometry and Red Blod Cell Alloimmunization in Pregnancy

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Determination of Fetomaternal Hemorrhage by Flow Cytometry and Red Blod Cell Alloimmunization in Pregnancy

Popis výsledku v původním jazyce

Background and Objectives The aim of the study was the quantitative determination of fetomaternal haemorrhage (FMH) by flow cytometry and red blood cell (RBC) antibody identification in pregnancy. Materials and Methods We present data from a prospective study of 94 women undergoing obstetric interventions from 12/2013 to 07/2014. FMH by flow cytometry using Anti-HbF, RBC antibody screening and ABO RhD blood group by serology was determined in peripheral blood anticoagulated blood samples. The RBC antibody screening was repeated six weeks or later in 51 women. Results Clinically significant FMH was founded in 9 cases of 94. We present 2 cases of excessive FMH. The first case was a spontaneous vaginal delivery at 40th week of pregnancy with a 4.9% FMH. The second case was acute caesarean section at 40th week of pregnancy with a 6.9% FMH. 8 from 94 samples contained RBC antibodies within the first examination immediately after obstetric procedure. 11 from 51 samples contained RBC antibodies within the second examination. Conclusion FMH with possible clinical significance was founded in 9 cases, excessive FMH only twice. We proved the presence of clinically significant and less significant antibodies caused by FMH after the actual or previous pregnancy.

Název v anglickém jazyce

Determination of Fetomaternal Hemorrhage by Flow Cytometry and Red Blod Cell Alloimmunization in Pregnancy

Popis výsledku anglicky

Background and Objectives The aim of the study was the quantitative determination of fetomaternal haemorrhage (FMH) by flow cytometry and red blood cell (RBC) antibody identification in pregnancy. Materials and Methods We present data from a prospective study of 94 women undergoing obstetric interventions from 12/2013 to 07/2014. FMH by flow cytometry using Anti-HbF, RBC antibody screening and ABO RhD blood group by serology was determined in peripheral blood anticoagulated blood samples. The RBC antibody screening was repeated six weeks or later in 51 women. Results Clinically significant FMH was founded in 9 cases of 94. We present 2 cases of excessive FMH. The first case was a spontaneous vaginal delivery at 40th week of pregnancy with a 4.9% FMH. The second case was acute caesarean section at 40th week of pregnancy with a 6.9% FMH. 8 from 94 samples contained RBC antibodies within the first examination immediately after obstetric procedure. 11 from 51 samples contained RBC antibodies within the second examination. Conclusion FMH with possible clinical significance was founded in 9 cases, excessive FMH only twice. We proved the presence of clinically significant and less significant antibodies caused by FMH after the actual or previous pregnancy.

Druh

J_ost - Ostatní články v recenzovaných periodicích

CEP obor

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OECD FORD obor

30205 - Hematology

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Annals of Hematology & Oncology

ISSN

2375-7965

e-ISSN

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Svazek periodika

5

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

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Kód UT WoS článku

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EID výsledku v databázi Scopus

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