TRANSCRANIAL SONOGRAPHY AND 123I-FP-CIT SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY IN MOVEMENT DISORDERS

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27661989%3A_____%2F14%3AN0000010" target="_blank" >RIV/27661989:_____/14:N0000010 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61989592:15110/14:33150662 RIV/00843989:_____/14:E0104146

Výsledek na webu

<a href="https://www.umbjournal.org/article/S0301-5629(14)00299-3/abstract" target="_blank" >https://www.umbjournal.org/article/S0301-5629(14)00299-3/abstract</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ultrasmedbio.2014.05.014" target="_blank" >10.1016/j.ultrasmedbio.2014.05.014</a>

Jazyk výsledku

angličtina

Název v původním jazyce

TRANSCRANIAL SONOGRAPHY AND 123I-FP-CIT SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY IN MOVEMENT DISORDERS

Popis výsledku v původním jazyce

Diagnosis of Parkinson's disease (PD) can be difficult in the early stages of the disease. The aim of the study described here was to assess the correlation between transcranial sonography (TCS) and I-123-FP-CIT ([I-123]ioflupane, N-omega-fluoropropyl-2 beta-carbomethoxy-3 beta-(4-[I-123]iodophenyl)nortropane) SPECT (single photon emission computed tomography) findings and the diagnosis of PD. A total of 49 patients were enrolled in the study: 29 patients with PD, 7 patients with other parkinsonian syndromes, 11 patients with essential tremor and 2 with psychogenic movement disorder. Substantia nigra echogenicity was measured using TCS. SPECT was performed using DaTSCAN ([I-123] ioflupane). TCS and SPECT findings were correlated in 84% of patients, with k = 0.62 (95% confidence interval: 0.38-0.86). TCS-measured substantia nigra echogenicity and SPECT-measured striatal binding ratio were negatively correlated (r = -0.326, p = 0.003). TCS/SPECT sensitivity, specificity and positive and negative predictive values for the diagnosis of PD were 89.7%/96.6%, 60.0%/70.0%, 76.5%/82.4% and 80.0%/93.3%, respectively. Both positive TCS and SPECT findings correlated significantly with the diagnosis of PD (k = 0.52, 95% confidence interval: 0.27-0.76, and k = 0.69, 95% confidence interval: 0.49-0.90, respectively). (C) 2014 World Federation for Ultrasound in Medicine & Biology.

Název v anglickém jazyce

TRANSCRANIAL SONOGRAPHY AND 123I-FP-CIT SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY IN MOVEMENT DISORDERS

Popis výsledku anglicky

Diagnosis of Parkinson's disease (PD) can be difficult in the early stages of the disease. The aim of the study described here was to assess the correlation between transcranial sonography (TCS) and I-123-FP-CIT ([I-123]ioflupane, N-omega-fluoropropyl-2 beta-carbomethoxy-3 beta-(4-[I-123]iodophenyl)nortropane) SPECT (single photon emission computed tomography) findings and the diagnosis of PD. A total of 49 patients were enrolled in the study: 29 patients with PD, 7 patients with other parkinsonian syndromes, 11 patients with essential tremor and 2 with psychogenic movement disorder. Substantia nigra echogenicity was measured using TCS. SPECT was performed using DaTSCAN ([I-123] ioflupane). TCS and SPECT findings were correlated in 84% of patients, with k = 0.62 (95% confidence interval: 0.38-0.86). TCS-measured substantia nigra echogenicity and SPECT-measured striatal binding ratio were negatively correlated (r = -0.326, p = 0.003). TCS/SPECT sensitivity, specificity and positive and negative predictive values for the diagnosis of PD were 89.7%/96.6%, 60.0%/70.0%, 76.5%/82.4% and 80.0%/93.3%, respectively. Both positive TCS and SPECT findings correlated significantly with the diagnosis of PD (k = 0.52, 95% confidence interval: 0.27-0.76, and k = 0.69, 95% confidence interval: 0.49-0.90, respectively). (C) 2014 World Federation for Ultrasound in Medicine & Biology.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30224 - Radiology, nuclear medicine and medical imaging

Projekt

—

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Ultrasound in Medicine & Biology

ISSN

0301-5629

e-ISSN

1879-291X

Svazek periodika

40

Číslo periodika v rámci svazku

10

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

7

Strana od-do

2365-2371

Kód UT WoS článku

000343144400006

EID výsledku v databázi Scopus

2-s2.0-84926211220