The fat mass, estimated glomerular filtration rate, and chronic inflammation in type 2 diabetic patients

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F27661989%3A_____%2F20%3A10002759" target="_blank" >RIV/27661989:_____/20:10002759 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61988987:17110/20:A210259H RIV/70883521:28110/20:63526107 RIV/70883521:28610/20:63526107

Výsledek na webu

<a href="https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcla.23229" target="_blank" >https://onlinelibrary.wiley.com/doi/epdf/10.1002/jcla.23229</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/jcla.23229" target="_blank" >10.1002/jcla.23229</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The fat mass, estimated glomerular filtration rate, and chronic inflammation in type 2 diabetic patients

Popis výsledku v původním jazyce

Background The aim of the study was to analyze the degree of obesity and its associations with age, gender, inflammation, an estimated glomerular filtration rate (eGFR), and liver function in type 2 diabetes mellitus (T2DM) patients.Methods A total of 874 consecutive adult Caucasian T2DM patients from outpatient diabetic clinic were included in the study. The relative fat mass (RFM) and body mass index (BMI) were used as obesity markers. Serum creatinine and cystatin C were used for the GFR estimation. Serum high-sensitive C-reactive protein (hsCRP) was used as the indicator of inflammation.Results The median, interquartile range (IQR) of RFM in females was higher than that in males (44.8 (42.3-47.2) % vs 31.3 (28.8-34.1) %, respectively; P &lt; .0001). The median (IQR) of BMI in females was no higher than that in males (30 (27-34) kg/m(2) vs 30 (27-34), respectively; P = .5152). The obesity prevalence was 99% in males and 98% in females according to RFM. BMI recognized obesity in 51% males and 53% females. RFM was positively associated with hsCRP in both males (r(s) = .296, P &lt; .0001) and females (r(s) = .445, P &lt; .0001). ALT was positively correlated with eGFRcys in both males (r(s) = .379, P &lt; .0001) and females (r(s) = .308, P &lt; .0001).Conclusion The RFM equation leads to higher obesity prevalence compared to BMI. Women have higher RFM compared to men. The kidney function was positively correlated with ALT serum concentrations.

Název v anglickém jazyce

The fat mass, estimated glomerular filtration rate, and chronic inflammation in type 2 diabetic patients

Popis výsledku anglicky

Background The aim of the study was to analyze the degree of obesity and its associations with age, gender, inflammation, an estimated glomerular filtration rate (eGFR), and liver function in type 2 diabetes mellitus (T2DM) patients.Methods A total of 874 consecutive adult Caucasian T2DM patients from outpatient diabetic clinic were included in the study. The relative fat mass (RFM) and body mass index (BMI) were used as obesity markers. Serum creatinine and cystatin C were used for the GFR estimation. Serum high-sensitive C-reactive protein (hsCRP) was used as the indicator of inflammation.Results The median, interquartile range (IQR) of RFM in females was higher than that in males (44.8 (42.3-47.2) % vs 31.3 (28.8-34.1) %, respectively; P &lt; .0001). The median (IQR) of BMI in females was no higher than that in males (30 (27-34) kg/m(2) vs 30 (27-34), respectively; P = .5152). The obesity prevalence was 99% in males and 98% in females according to RFM. BMI recognized obesity in 51% males and 53% females. RFM was positively associated with hsCRP in both males (r(s) = .296, P &lt; .0001) and females (r(s) = .445, P &lt; .0001). ALT was positively correlated with eGFRcys in both males (r(s) = .379, P &lt; .0001) and females (r(s) = .308, P &lt; .0001).Conclusion The RFM equation leads to higher obesity prevalence compared to BMI. Women have higher RFM compared to men. The kidney function was positively correlated with ALT serum concentrations.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20602 - Medical laboratory technology (including laboratory samples analysis; diagnostic technologies) (Biomaterials to be 2.9 [physical characteristics of living material as related to medical implants, devices, sensors])

Projekt

—

Návaznosti

N - Vyzkumna aktivita podporovana z neverejnych zdroju

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Clinical Laboratory Analysis

ISSN

0887-8013

e-ISSN

1098-2825

Svazek periodika

34

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

nestránkováno

Kód UT WoS článku

000512423000001

EID výsledku v databázi Scopus

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