Carbosilane cationic dendrimers synthesized by thiol-ene click chemistry and their use as antibacterial agents
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13440%2F14%3A43885156" target="_blank" >RIV/44555601:13440/14:43885156 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1039/c3ra45408h" target="_blank" >http://dx.doi.org/10.1039/c3ra45408h</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c3ra45408h" target="_blank" >10.1039/c3ra45408h</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Carbosilane cationic dendrimers synthesized by thiol-ene click chemistry and their use as antibacterial agents
Popis výsledku v původním jazyce
Cationic carbosilane dendrimers of generations 1-3 have been synthesized employing thiol-ene click chemistry. The obtained dendrimers present three different types of ammonium functions, two of them with the charge at the surface, -NH3 + and -NMe3 +, andother with the charge internalized by the presence of ethylalcohol moieties, -[NMe2(CH2CH2OH)]+. The influence of -NMe3 + and -[NMe2(CH2CH2OH)]+ in dendrimer structure have been studied by molecular dynamics. The antibacterial properties of these families of dendrimers have been evaluated against Gram-positive (Staphylococcus aureus CECT 240) and Gramnegative (Escherichia coli CECT 515) bacterial strains, and the results have been compared with those obtained for related cationic carbosilane dendrimersfunctionalized by hydrosilylation reactions. These data show the relevance of the sulfur atom versus the silicon atom close to the dendrimer surface and the outer charge versus the inner charge. Finally, the stability of the most active
Název v anglickém jazyce
Carbosilane cationic dendrimers synthesized by thiol-ene click chemistry and their use as antibacterial agents
Popis výsledku anglicky
Cationic carbosilane dendrimers of generations 1-3 have been synthesized employing thiol-ene click chemistry. The obtained dendrimers present three different types of ammonium functions, two of them with the charge at the surface, -NH3 + and -NMe3 +, andother with the charge internalized by the presence of ethylalcohol moieties, -[NMe2(CH2CH2OH)]+. The influence of -NMe3 + and -[NMe2(CH2CH2OH)]+ in dendrimer structure have been studied by molecular dynamics. The antibacterial properties of these families of dendrimers have been evaluated against Gram-positive (Staphylococcus aureus CECT 240) and Gramnegative (Escherichia coli CECT 515) bacterial strains, and the results have been compared with those obtained for related cationic carbosilane dendrimersfunctionalized by hydrosilylation reactions. These data show the relevance of the sulfur atom versus the silicon atom close to the dendrimer surface and the outer charge versus the inner charge. Finally, the stability of the most active
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CC - Organická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
RSC Advances
ISSN
2046-2069
e-ISSN
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Svazek periodika
4
Číslo periodika v rámci svazku
3
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
10
Strana od-do
1256-1265
Kód UT WoS článku
000327868400035
EID výsledku v databázi Scopus
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