Synthesis of new anionic carbosilane dendrimers via thiol-ene chemistry and their antiviral behaviour
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13440%2F14%3A43885809" target="_blank" >RIV/44555601:13440/14:43885809 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.1039/c4ob00162a" target="_blank" >http://dx.doi.org/10.1039/c4ob00162a</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1039/c4ob00162a" target="_blank" >10.1039/c4ob00162a</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Synthesis of new anionic carbosilane dendrimers via thiol-ene chemistry and their antiviral behaviour
Popis výsledku v původním jazyce
A synthetic strategy has been developed for the preparation of anionic carbosilane dendrimers bearing sulfonate or carboxylate groups at their periphery by means of thiol-ene chemistry. It offers significant advantages, such as milder reaction conditions, shorter reaction times and more facile purification methods, when compared with other synthetic protocols used previously, e.g. hydrosilylation followed by a Michael-type addition or azide-alkyne coupling reactions. Molecular dynamics simulations of the second generation anionic dendrimers addressing shape and size effects of the terminal groups and conformational variability indicated that the core eccentricity and flexibility might need to be taken into account for toxicity and interaction with viral and/or cellular receptors, respectively. The biocompatibility of anionic carbosilane dendrimers has been explored showing differences between silicon-cored and polyphenoxo-cored dendrimers. In addition, silicon-cored dendrimers achieved
Název v anglickém jazyce
Synthesis of new anionic carbosilane dendrimers via thiol-ene chemistry and their antiviral behaviour
Popis výsledku anglicky
A synthetic strategy has been developed for the preparation of anionic carbosilane dendrimers bearing sulfonate or carboxylate groups at their periphery by means of thiol-ene chemistry. It offers significant advantages, such as milder reaction conditions, shorter reaction times and more facile purification methods, when compared with other synthetic protocols used previously, e.g. hydrosilylation followed by a Michael-type addition or azide-alkyne coupling reactions. Molecular dynamics simulations of the second generation anionic dendrimers addressing shape and size effects of the terminal groups and conformational variability indicated that the core eccentricity and flexibility might need to be taken into account for toxicity and interaction with viral and/or cellular receptors, respectively. The biocompatibility of anionic carbosilane dendrimers has been explored showing differences between silicon-cored and polyphenoxo-cored dendrimers. In addition, silicon-cored dendrimers achieved
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CD - Makromolekulární chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/GA13-06989S" target="_blank" >GA13-06989S: Plazmo-chemické modifikace fylosilikátů pro funkční nanostruktury</a><br>
Návaznosti
P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Organic & Biomolecular Chemistry
ISSN
1477-0520
e-ISSN
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Svazek periodika
12
Číslo periodika v rámci svazku
20
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
16
Strana od-do
3222-3237
Kód UT WoS článku
000335336800010
EID výsledku v databázi Scopus
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