Synthesis of bow-tie carbosilane dendrimers and their HIV antiviral capacity: A comparison of the dendritic topology on the biological process

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13440%2F19%3A43894892" target="_blank" >RIV/44555601:13440/19:43894892 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0014305719310948?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0014305719310948?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.eurpolymj.2019.07.034" target="_blank" >10.1016/j.eurpolymj.2019.07.034</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis of bow-tie carbosilane dendrimers and their HIV antiviral capacity: A comparison of the dendritic topology on the biological process

Popis výsledku v původním jazyce

A simple and versatile synthetic approach was designed for the formation of sulfonate-terminated bow-tie carbosilane dendrimers with different cores as hydroquinone moiety, triazol ring or carbamate group. These systems were designed to compare biological and biomedical properties attending to the shape or topology of the carbosilane dendritic systems: spherical, dendrons and bow-tie architectures. Biocompatibility and HIV antiviral activity were measured in TZM.bl cells as human epithelial cell line. Sulfonate groups at the periphery of the dendritic systems were selected due to the ability of previously reported anionic dendrimers to interact with important receptor in viral infection. Finally, experimental results were compared with theoretical data showing a clear relationship between topology and biological activity, being a parameter to consider for exploring biomedical applications.

Název v anglickém jazyce

Synthesis of bow-tie carbosilane dendrimers and their HIV antiviral capacity: A comparison of the dendritic topology on the biological process

Popis výsledku anglicky

A simple and versatile synthetic approach was designed for the formation of sulfonate-terminated bow-tie carbosilane dendrimers with different cores as hydroquinone moiety, triazol ring or carbamate group. These systems were designed to compare biological and biomedical properties attending to the shape or topology of the carbosilane dendritic systems: spherical, dendrons and bow-tie architectures. Biocompatibility and HIV antiviral activity were measured in TZM.bl cells as human epithelial cell line. Sulfonate groups at the periphery of the dendritic systems were selected due to the ability of previously reported anionic dendrimers to interact with important receptor in viral infection. Finally, experimental results were compared with theoretical data showing a clear relationship between topology and biological activity, being a parameter to consider for exploring biomedical applications.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30309 - Tropical medicine

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Polymer Journal

ISSN

0014-3057

e-ISSN

—

Svazek periodika

2019

Číslo periodika v rámci svazku

119

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

13

Strana od-do

200-212

Kód UT WoS článku

000489191900024

EID výsledku v databázi Scopus

2-s2.0-85069937451