An Effectiveness Evaluation of Information Technology of Gene Expression Profiles Processing for Gene Networks Reconstruction
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13440%2F18%3A43893760" target="_blank" >RIV/44555601:13440/18:43893760 - isvavai.cz</a>
Výsledek na webu
<a href="http://dx.doi.org/10.5815/ijisa.2018.07.01" target="_blank" >http://dx.doi.org/10.5815/ijisa.2018.07.01</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.5815/ijisa.2018.07.01" target="_blank" >10.5815/ijisa.2018.07.01</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
An Effectiveness Evaluation of Information Technology of Gene Expression Profiles Processing for Gene Networks Reconstruction
Popis výsledku v původním jazyce
The paper presents the research results concerning an effectiveness evaluation of information technology of gene expression profiles processing for purpose of gene regulatory networks reconstruction. The information technology is presented as a structural block-chart of step-by-step stages of the studied data processing. The DNA microchips of patients, who were investigated on different types of cancer, were used as experimental data. The optimal parameters of data processing algorithm at appropriate stage of this process implementation by quantity criteria of data processing quality were determined during simulation. Validation of the reconstructed gene networks was performed with the use of ROC-analysis by comparison of character of genes interconnection in both the basic network and networks reconstructed based on the obtained biclusters.
Název v anglickém jazyce
An Effectiveness Evaluation of Information Technology of Gene Expression Profiles Processing for Gene Networks Reconstruction
Popis výsledku anglicky
The paper presents the research results concerning an effectiveness evaluation of information technology of gene expression profiles processing for purpose of gene regulatory networks reconstruction. The information technology is presented as a structural block-chart of step-by-step stages of the studied data processing. The DNA microchips of patients, who were investigated on different types of cancer, were used as experimental data. The optimal parameters of data processing algorithm at appropriate stage of this process implementation by quantity criteria of data processing quality were determined during simulation. Validation of the reconstructed gene networks was performed with the use of ROC-analysis by comparison of character of genes interconnection in both the basic network and networks reconstructed based on the obtained biclusters.
Klasifikace
Druh
J<sub>SC</sub> - Článek v periodiku v databázi SCOPUS
CEP obor
—
OECD FORD obor
10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)
Návaznosti výsledku
Projekt
—
Návaznosti
N - Vyzkumna aktivita podporovana z neverejnych zdroju
Ostatní
Rok uplatnění
2018
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
International Journal of Intelligent Systems and Applications
ISSN
2074-904X
e-ISSN
—
Svazek periodika
2018
Číslo periodika v rámci svazku
10(7)
Stát vydavatele periodika
CN - Čínská lidová republika
Počet stran výsledku
10
Strana od-do
1-10
Kód UT WoS článku
—
EID výsledku v databázi Scopus
2-s2.0-85049405773