Applying Convolutional Neural Network for Cancer Disease Diagnosis Based on Gene Expression Data

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13440%2F23%3A43898152" target="_blank" >RIV/44555601:13440/23:43898152 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.scopus.com/record/display.uri?eid=2-s2.0-85182265720&origin=resultslist" target="_blank" >https://www.scopus.com/record/display.uri?eid=2-s2.0-85182265720&origin=resultslist</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Applying Convolutional Neural Network for Cancer Disease Diagnosis Based on Gene Expression Data

Popis výsledku v původním jazyce

Applying deep learning techniques, such as convolutional or recurrent neural networks, to process gene expression data for developing complex disease diagnostic systems is one of modern bioinformatics&apos;s current focuses. Deep learning algorithms can identify specific patterns in the hierarchical representation of data and craft distinct functions that allow for precise identification of the subjects being studied. In this paper, we present our research findings on applying a convolutional neural network (CNN) in diagnosing various types of cancer based on gene expression data. The experimental data were sourced from The Cancer Genome Atlas (TCGA) and comprised 3269 samples. These samples can be categorized into nine classes based on the type of cancer. We introduced an ordered search-by-grid algorithm to pinpoint the optimal set of hyperparameters for the CNN. We assessed the model&apos;s efficacy using classification quality metrics, considering type I and II errors. Furthermore, we introduced an integrated F1-score index, drawing from the Harrington desirability function. The obtained results demonstrate the high efficacy of our proposed approach in diagnosing cancer based on gene expression data. The simulation results have shown that the single-layer CNN is more efficient for this type of data by all classification quality criteria. The number of correctly identified samples was 955 out of 981. The classification accuracy was 97.3%.

Název v anglickém jazyce

Applying Convolutional Neural Network for Cancer Disease Diagnosis Based on Gene Expression Data

Popis výsledku anglicky

Applying deep learning techniques, such as convolutional or recurrent neural networks, to process gene expression data for developing complex disease diagnostic systems is one of modern bioinformatics&apos;s current focuses. Deep learning algorithms can identify specific patterns in the hierarchical representation of data and craft distinct functions that allow for precise identification of the subjects being studied. In this paper, we present our research findings on applying a convolutional neural network (CNN) in diagnosing various types of cancer based on gene expression data. The experimental data were sourced from The Cancer Genome Atlas (TCGA) and comprised 3269 samples. These samples can be categorized into nine classes based on the type of cancer. We introduced an ordered search-by-grid algorithm to pinpoint the optimal set of hyperparameters for the CNN. We assessed the model&apos;s efficacy using classification quality metrics, considering type I and II errors. Furthermore, we introduced an integrated F1-score index, drawing from the Harrington desirability function. The obtained results demonstrate the high efficacy of our proposed approach in diagnosing cancer based on gene expression data. The simulation results have shown that the single-layer CNN is more efficient for this type of data by all classification quality criteria. The number of correctly identified samples was 955 out of 981. The classification accuracy was 97.3%.

Druh

W - Uspořádání workshopu

CEP obor

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OECD FORD obor

10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

Projekt

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Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Místo konání akce

Bratislava

Stát konání akce

SK - Slovenská republika

Datum zahájení akce

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Datum ukončení akce

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Celkový počet účastníků

120

Počet zahraničních účastníků

85

Typ akce podle státní přísl. účastníků

WRD - Celosvětová akce