Simulation of the effect of ethanol on DNA damage by ionizing radiation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F44555601%3A13440%2F24%3A43898696" target="_blank" >RIV/44555601:13440/24:43898696 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.tandfonline.com/doi/full/10.1080/10420150.2024.2424755" target="_blank" >https://www.tandfonline.com/doi/full/10.1080/10420150.2024.2424755</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/10420150.2024.2424755" target="_blank" >10.1080/10420150.2024.2424755</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Simulation of the effect of ethanol on DNA damage by ionizing radiation

Popis výsledku v původním jazyce

The presence of ethanol in the water solution during irradiation by ionizing radiation decreases the number of OH and H radicals. Since the living cell is mainly composed of water, this causes less damage to the DNA molecule irradiated by low-LET ionizing radiation where an indirect effect prevails. Ethanol thus acts as a radioprotective substance, scavenging radicals H and OH. This fact can be used in various practical applications in which living cells are irradiated by ionizing radiation to protect them. We used hybrid Petri nets to simulate all dynamic processes, including chemical reactions and the simultaneous diffusion of radical clusters. The mathematical simulatingmodel enables us to simulate the damage to the DNA moleculeby the radical cluster arising at various distances from this molecule.

Název v anglickém jazyce

Simulation of the effect of ethanol on DNA damage by ionizing radiation

Popis výsledku anglicky

The presence of ethanol in the water solution during irradiation by ionizing radiation decreases the number of OH and H radicals. Since the living cell is mainly composed of water, this causes less damage to the DNA molecule irradiated by low-LET ionizing radiation where an indirect effect prevails. Ethanol thus acts as a radioprotective substance, scavenging radicals H and OH. This fact can be used in various practical applications in which living cells are irradiated by ionizing radiation to protect them. We used hybrid Petri nets to simulate all dynamic processes, including chemical reactions and the simultaneous diffusion of radical clusters. The mathematical simulatingmodel enables us to simulate the damage to the DNA moleculeby the radical cluster arising at various distances from this molecule.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10201 - Computer sciences, information science, bioinformathics (hardware development to be 2.2, social aspect to be 5.8)

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Radiation effects and defects in solids

ISSN

1042-0150

e-ISSN

1029-4953

Svazek periodika

2024

Číslo periodika v rámci svazku

"necislovano"

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

14

Strana od-do

"nestrankovano"

Kód UT WoS článku

001365793300001

EID výsledku v databázi Scopus

2-s2.0-85210566702