Nanofiber morphology optimalization for using as tubular artificial blood vessels

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24410%2F13%3A%230001757" target="_blank" >RIV/46747885:24410/13:#0001757 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Nanofiber morphology optimalization for using as tubular artificial blood vessels

Popis výsledku v původním jazyce

Electrospinning of polymer solution leads to the nanofibrous mats mimicking the structure of native extracellular matrix. The modification of electrospinning setup with a rotating mandrel collector results in deposition of nanofibers onto a tubular scaffold being used as vascular grafts. Polycaprolactone (PCL) is one of the most used polymers thanks to its excellent properties such as biocompatibility, biodegradability and mechanical strength. In this study, multilayer structure composed of PCL was designed for scaffold fabrication comparable to the structure of native vessels in human body. Inner layer of the scaffold is composed of thin fibers whereas the outer layer is formed by thick fibers in order to control the pore size for target cell type. Moreover, orientation of the fibers was investigated with adjusting the speed of rotating mandrel to improve cell adhesion. Electrospinning parameters for production of each layer were optimized and final vascular graft was mechanically tes

Název v anglickém jazyce

Nanofiber morphology optimalization for using as tubular artificial blood vessels

Popis výsledku anglicky

Electrospinning of polymer solution leads to the nanofibrous mats mimicking the structure of native extracellular matrix. The modification of electrospinning setup with a rotating mandrel collector results in deposition of nanofibers onto a tubular scaffold being used as vascular grafts. Polycaprolactone (PCL) is one of the most used polymers thanks to its excellent properties such as biocompatibility, biodegradability and mechanical strength. In this study, multilayer structure composed of PCL was designed for scaffold fabrication comparable to the structure of native vessels in human body. Inner layer of the scaffold is composed of thin fibers whereas the outer layer is formed by thick fibers in order to control the pore size for target cell type. Moreover, orientation of the fibers was investigated with adjusting the speed of rotating mandrel to improve cell adhesion. Electrospinning parameters for production of each layer were optimized and final vascular graft was mechanically tes

Druh

O - Ostatní výsledky

CEP obor

JJ - Ostatní materiály

OECD FORD obor

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Projekt

<a href="/cs/project/GAP208%2F12%2F0105" target="_blank" >GAP208/12/0105: ROZTOKY POLYMERŮ VE VNĚJŠÍM POLI: MOLEKULÁRNÍ POCHOPENÍ ELEKTROSPINNINGU</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů