Mechanical investigation of bilayer vascular grafts electrospun from aliphatic polyesters

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F46747885%3A24410%2F16%3A00004041" target="_blank" >RIV/46747885:24410/16:00004041 - isvavai.cz</a>

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1002/pat.3875/abstract" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/pat.3875/abstract</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/pat.3875" target="_blank" >10.1002/pat.3875</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mechanical investigation of bilayer vascular grafts electrospun from aliphatic polyesters

Popis výsledku v původním jazyce

Electrospun biodegradable vascular grafts provide a wide range of design components from the selection of materials to the modification of fiber structure. In this study, both single layer and bilayer tubular scaffolds with inner diameter of 6 mm were electrospun from polycaprolactone with different molecular weights and poly(l-lactide) caprolactone polymers. Bilayer scaffolds were designed by using different combinations of the polymer types in each layer and obtaining fiber orientation in outer layers. Scaffolds were analyzed morphologically and mechanically. Obtained results of mechanical performance were discussed according to the used polymer-type composition, fiber orientation, and composite effect of both layer in the final graft. Smooth muscle cells were seeded on the scaffolds to test biocompatibility of presented scaffolds. Results indicate that the use of different biodegradable polymers in different combinations in each layer causes notable differences in fiber morphology and mechanical performance of the scaffolds. Moreover, fiber orientation in outer layer improves tensile strength and burst pressures in radial directions while creating a suitable fibrous layer for smooth muscle cells by mimicking the extracellular matrix of tunica media in native vessels.

Název v anglickém jazyce

Mechanical investigation of bilayer vascular grafts electrospun from aliphatic polyesters

Popis výsledku anglicky

Electrospun biodegradable vascular grafts provide a wide range of design components from the selection of materials to the modification of fiber structure. In this study, both single layer and bilayer tubular scaffolds with inner diameter of 6 mm were electrospun from polycaprolactone with different molecular weights and poly(l-lactide) caprolactone polymers. Bilayer scaffolds were designed by using different combinations of the polymer types in each layer and obtaining fiber orientation in outer layers. Scaffolds were analyzed morphologically and mechanically. Obtained results of mechanical performance were discussed according to the used polymer-type composition, fiber orientation, and composite effect of both layer in the final graft. Smooth muscle cells were seeded on the scaffolds to test biocompatibility of presented scaffolds. Results indicate that the use of different biodegradable polymers in different combinations in each layer causes notable differences in fiber morphology and mechanical performance of the scaffolds. Moreover, fiber orientation in outer layer improves tensile strength and burst pressures in radial directions while creating a suitable fibrous layer for smooth muscle cells by mimicking the extracellular matrix of tunica media in native vessels.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

JJ - Ostatní materiály

OECD FORD obor

—

Projekt

<a href="/cs/project/NV15-29241A" target="_blank" >NV15-29241A: Nanovlákenná biodegradabilní maloprůměrová cévní náhrada</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Polymers for Advanced Technologies

ISSN

1099-1581

e-ISSN

—

Svazek periodika

28

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

13

Strana od-do

201-213

Kód UT WoS článku

000393706200008

EID výsledku v databázi Scopus

2-s2.0-84989232435